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Regional assignment of the human C1-inhibitor gene to 11q11–q13.1


In situ hybridisation using a biotinylated 1.8kb human cDNA clone in both normal and structurally abnormal chromosomes supports regional localisation of the gene for human C1-inhibitor to chromosome 11q11-q13.11.

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  1. Bock SC, Skriver K, Nielsen E, Wiman B, Donaldson VH, Eddy RL, Marriman J, Radziefiwska E, Huber R, Shows TB (1986) Human C1-inhibitor: primary structure, cDNA cloning and chromosomal localisation. Biochemistry 25:4292–4301

  2. Boyd E, Theriault A, Goddard JP, Kalaitsidaki M, Spathas DH, Connor JM (1989) Chromosomal assignment of a glutamic acid transfer RNA (tRNAGlu) gene to 1p36. Hum Genet 81:153–156

  3. Davis AE, Whitehead AS, Harrison RA, Danphinais A, Bruns GAP, Cicardi M, Rosen FS (1986) Human inhibitor of the first component, C1, characterisation of cDNA clones and localisation of the gene to chromosome 11. Proc Natl Acad Sci USA 83:3161–3165

  4. Fukushima Y, Byers MG, Bock S, Shows TB (1987) The human C1 inhibitor gene (C1NH) is located at 11q12–13.1 (abstract). (9th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 46:617

  5. Garson JA, Berghe JA van den, Kemshead JT (1987) High resolution in situ hybridisation technique using biotinylated NHYC oncogene probe reveals periodic structure of HSRs in human neuroblastoma. Cytogenet Cell Genet 45:10–15

  6. Kerr MA, Yeung-Laiwah AC (1987) C1-inhibitor deficiency and angio oedema. In: Whaley K (ed) Complement in health and disease. MTP Press, Lancaster, pp 53–78

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Correspondence to J. M. Connor.

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Theriault, A., Whaley, K., McPhaden, A.R. et al. Regional assignment of the human C1-inhibitor gene to 11q11–q13.1. Hum Genet 84, 477–479 (1990).

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  • Internal Medicine
  • Metabolic Disease
  • cDNA Clone
  • Regional Localisation
  • Abnormal Chromosome