The human aldose reductase (AR) gene has been mapped to chromosome 7 using the polymerase chain reaction to specifically amplify the human AR sequence in hamster/human hybrid DNA and also in mouse/ human monochromosome hybrids. The assignment to chromosome 7 was confirmed by in situ hybridisation to human metaphase chromosomes using a novel, rapid hybridisation, method giving a regional localisation at 7q35.
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Graham, A., Heath, P., Morten, J.E.N. et al. The human aldose reductase gene maps to chromosome region 7q35. Hum Genet 86, 509–514 (1991). https://doi.org/10.1007/BF00194644
- Polymerase Chain Reaction
- Internal Medicine
- Metabolic Disease
- Regional Localisation
- Chromosome Region