Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

The human aldose reductase gene maps to chromosome region 7q35


The human aldose reductase (AR) gene has been mapped to chromosome 7 using the polymerase chain reaction to specifically amplify the human AR sequence in hamster/human hybrid DNA and also in mouse/ human monochromosome hybrids. The assignment to chromosome 7 was confirmed by in situ hybridisation to human metaphase chromosomes using a novel, rapid hybridisation, method giving a regional localisation at 7q35.

This is a preview of subscription content, log in to check access.


  1. Abbott C, West L, Povey S, Jeremiah S, Murad Z, DiScipio R, Fey G (1989) The gene for human complement component C9 mapped to chromosome 5 by polymerase chain reaction. Genomics 4:606–609

  2. Aghamahammadi SZ, Savage JRK (1989) A pulse BrdU method for SCE Mutat Res 216:259–266

  3. Anand R, Riley JH, Butler R, Smith JC, Markham AF (1990) A 3. 5 genome equivalent multi-access YAC library: construction, characterisation, screening and storage. Nucleic Acids Res 18:1951–1956

  4. Bohren KM, Bullock B, Wermuth B, Gabbay KH (1989) The aldo-keto reductase superfamily. J Biol Chem 264:9547–9551

  5. Chung S, La Mendola J (1989) Cloning and sequence determination of human placental aldose reductase gene. J Biol Chem 264:14775–14777

  6. Dean M, Park M, LeBeau MM, Robins TS, Diaz MO, Rowley JD, Blair DG, Van de Woude GF (1985) The human met oncogene is related to the tyrosine kinase oncogenes. Nature 318:385–388

  7. Dionne CA, Kaplan R, Seuanez H, O'Brien SJ, Jaye M (1990) Chromosome assignment by PCR techniques: assignment of the oncogene FGF-5 to human chromosome 4. Biotechniques 8:190–194

  8. Duncan AMV, Buchwald M, Tsui L-C (1988) In situ hybridisation of two cloned chromosome 7 sequences tightly linked to the cystic fibrosis locus. Cytogenet Cell Genet 49:309–310

  9. Elvin P, Slynn G, Black D, Graham A, Butler R, Riley JH, Anand R, Markham AF (1990) Isolation of cDNA clones using yeast artificial chromosome probes. Nucleic Acids Res 18:3913–3917

  10. Graham A, Hedge PJ, Powell SJ, Riley J, Brown L, Gammack AJ, Carey F, Markham AF (1989) Nucleotide sequence of cDNA for human aldose reductase. Nucleic Acids Res 17:8368

  11. Graham A, Brown L, Hedge PJ, Gammack AJ, Markham AF (1991) Structure of the human aldose reductase gene. J Biol Chem (in press)

  12. Grundmann U, Bohn H, Obermeier R, Amann E (1990) Cloning and prokaryotic expression of a biologically active human placental aldose reductase. DNA Cell Biol 9:149–157

  13. ISCN (1985) An international system for human cytogenetic nomenclature. In: Harnden DG, Klinger HP (eds) Published in collaboration with Cytogenet Cell Genet. Kargel, Basel

  14. McNeill C, Brown R (1980) Genetic manipulation by means of microcell-mediated transfer of normal human chromosomes into recipient mouse cells. Proc Natl Acad Sci USA 77:5394–5398

  15. Riordan JR, Rommens JM, Kerem B, Alon N, Rozmahel R, Grzelczak Z, Zielenski J, Lok S, Plavsic N, Chou J-L, Drumm ML, Iannuzzi MC, Collins FS, Tsui L-C (1989) Identification of the cystic fibrosis gene: cloning and characterisation of complementary DNA. Science 245:1066–1073

  16. Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Erlich HA, Arnheim N (1985) Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anaemia. Science 230:1350–1354

  17. Saxon PJ, Srivatsan ES, Leipzig GV, Sameshima JG, Stanbridge EJ (1985) Selective transfer of individual human chromosomes to recipient cells. Mol Cell Biol 5:140–146

  18. Saxon PJ, Srivatsan ES, Stanbridge EJ (1986) Introduction of human chromosome 11 via microcell transfer controls tumorogenic expression of Hela cells. EMBO J 5:3461–3466

  19. Van Steeg H, Van Oostrom CTM, Martens JWM, Van Kreyl CF, Schepens J, Wieringa B (1989) Nucleotide sequence of the uman ornithine decarboxylase gene. Nucleic Acids Res 17:8855–8856

  20. Yang-Feng TL, Opdenakker G, Volckaert G, Francke U (1985) Mapping of the human tissue-type plasminogen activator (PLAT) gene to chromosome 8 (8p12–q11.2). Cytogenet Cell Genet 40:784

Download references

Author information

Correspondence to Alexander Graham.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Graham, A., Heath, P., Morten, J.E.N. et al. The human aldose reductase gene maps to chromosome region 7q35. Hum Genet 86, 509–514 (1991). https://doi.org/10.1007/BF00194644

Download citation


  • Polymerase Chain Reaction
  • Internal Medicine
  • Metabolic Disease
  • Regional Localisation
  • Chromosome Region