Pibenzimol is a fluorescent molecule known to bind to double stranded DNA. It also induces prolongation of the G2 phase of the cell cycle, inhibition of DNA replication and cessation of the growth of some cells in late S phase after DNA content has been doubled. It has been shown to increase the life span of mice bearing intraperitoneally implanted L1210 and P388 leukemia. These factors coupled with the affinity of pibenzimol for pancreatic tissue led us to conduct a phase I–II trial of pibenzimol hydrochloride in patients with advanced pancreatic cancer. Twenty-six patients were treated with a five day continuous infusion of pibenzimol at a dose ranging from 6–28 mg/m2/d. There were no treatment related deaths. Major toxicity was hyperglycemia which was self-limited. No objective responses were noted.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Laemmler G, Raether W: Chemotherapeutic experiments with a 2,6-bis-benzimidazole in cotton rats infected with litomosoides carinii. Proceedings of the Eighth International Congresses of Tropical Medicine and Malaria, Teheran 139, 1968
Laemmler G, Herzog H, Saupe E, Schuetze HR: Chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. Bull WHO 44: 741–756, 1971
Hirschberg J, Lavi U, Goiten R, Marcus M: The pleiotropic effects of 33258-hoechst on the cell cycle in Chinese hamster cells in vitro. Exp Cell Res 130: 63–72, 1980
Marcus M, Sperling K: Condensation-inhibition by 33258-hoechst of centromeric heterochromatin in prematurely condensed mouse chromosomes. Exp Cell Res 123: 406–411, 1979
Marcus M, Nielsen K, Goitein R, Gropp A: Pattern of condensation of mouse and Chinese hamster chromosomes in G2 and mitosis of 33258-hoechst-treated cells. Exp Cell Res 122: 191–201, 1979
Kusyk CJ, Hsu TC: Induction of high frequencies of endoreduplication if mammalian cell cultures with 33258-hoechst and rubidazone. Cytogenet Cell Genet 23: 39–43, 1979
NCI Clinical Brochure. Pibenzimol, NSC-322921, IND-23268, the revised version. DCT, NCI, Bethesda, MD. March 1984.
Kraut E, Malspeis L, Balcerzak S, Grever M. Evaluation of pibenzimol (NSC 322921) in refractory solid malignancies. Proc ASCO 7: 62, 1988
Ames MM, Miller KJ, Moertel DM: High performance liquid Chromatographic assay and preclinical pharmacological studies of pibenzimol (Bisbenzimidazole), J O Chromatog, Biomed Applications 341: 89–96, 1985
About this article
Cite this article
Patel, S.R., Kvols, L.K., Rubin, J. et al. Phase I–II study of pibenzimol hydrochloride (NSC 322921) in advanced pancreatic carcinoma. Invest New Drugs 9, 53–57 (1991). https://doi.org/10.1007/BF00194545
- pancreatic cancer
- phase I trial