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The human QARS locus: assignment of the human gene for glutaminyl-tRNA synthetase to chromosome 1q32–42

Summary

We have used a cDNA encoding the core region of the human glutaminyl-tRNA synthetase to determine the chromosomal localization of the corresponding gene. Southern blots of restricted DNA from a panel of rodent-human cell lines and in situ chromosome hybridization gave identical results showing that the human gene locus for glutaminyl-tRNA synthetase resides on the distal long arm of chromosome 1. There are now nine mapped aminoacyl-tRNA synthetase genes in the human genome.

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Correspondence to R. Knippers.

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Kunze, N., Bittler, E., Fett, R. et al. The human QARS locus: assignment of the human gene for glutaminyl-tRNA synthetase to chromosome 1q32–42. Hum Genet 85, 527–530 (1990). https://doi.org/10.1007/BF00194231

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Keywords

  • Internal Medicine
  • Metabolic Disease
  • Human Genome
  • Southern Blot
  • Gene Locus