We report a case of primary aneurysmal cyst of soft tissues in a 57-year-old woman presenting with a painful mass in her left arm. Conventional radiography showed a radiolucent soft tissue mass surrounded by a ring of bone. MRI displayed an unusual, ill-defined soft tissue lesion that was not connected to the nearby humerus and appeared to be an aggressive tumour. Microscopically, the mass consisted of multiple anastomosing cavernous channels surrounded by a peripheral band of mature trabecular bone. These bloody channels were separated by fibrous septa containing fibroblasts, histiocytes and multinucleated giant cells, as well as fibromyxochondroid material. Some of these giant cells lined the septa and partially occupied the lumen of the channels. Ultrastructurally, the features observed in this tumour were similar to those described in aneurysmal bone cyst; the giant cells lining the septa were an additional observation. Whereas most bone tumours have a well-known extraosseous counterpart, this unique lesion is not well recognized by surgical pathologists and the few published cases have been reported under different names. Gross, microscopic, radiological and ultrastructural findings are presented to familiarize pathologists with this underdiagnosed condition.
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Aho HJ, Aho AJ, Einola S (1982) Aneurysmal bone cyst, a study of ultrastructure and malignant transformation. Virchows Arch [A] 395:169–179
Alles JU, Schulz A (1986) Immunocytochemical markers (endothelial and histiocytic) and ultrastructure of primary aneurysmal bone cyst. Hum Pathol 17:39–45
Amir G, Mogle P, Sucher E (1992) Case report 729. Myositis ossificans and aneurysmal bone cyst. Skeletal Radiol 21:257–259
Beltran J, Simon DC, Levy M, Herman L, Weis L, Mueller CF (1986) Aneurysmal bone cysts: MR imaging at 1.5 T1. Radiology 158:689–690
Bonakdarpour A, Levy WM, Aegeter E (1978) Primary and secondary aneurysmal bone cyst: a radiological study of 75 cases. Radiology 126:75–83
Campana R, Betelli G, Biagini R, Ruggieri P, Bertoni F, Campanaci M (1985) Aneurysmal cyst of long bones. Ital J Orthop Traumatol 11:409–417
Campanacci M, Campanna R, Picci P (1986) Unicameral and aneurysmal bone cysts. Clin Orthop 204:25–36
Dahlin DC, McLeod RA (1982) Aneurysmal bone cyst and other non-neoplastic conditions. Skeletal Radiol 8:243–250
Dahlin DC, Unni KK (1986) Bone tumors. Conditions that commonly simulate primary neoplasms of bone. In: Dahlin DC, Unni KK (eds) General aspects and data on 8,542 cases. Thomas, Springfield, pp 406–481
Frassica FJ, Amadio PC, Wold LE, Beabout JW (1988) Aneurysmal bone cyst: clinicopathologic features and treatment of ten cases involving the hand. J Hand Surg [Am] 13:676–683
Jaffe HL, Lichtenstein L (1942) Solitary unicameral bone cyst: with emphasis on the roentgen picture, the pathologic appearances and the pathogenesis. Arch Surg 44:1004–1025
Levy WM, Miller AS, Bonakdarpour A, Aegeter E (1975) Aneurysmal bone cyst secondary to other osseous lesions. Report of 57 cases. Am J Clin Pathol 63:1–8
Martinez V, Sissons HA (1988) Aneurysmal bone cyst: a review of 123 cases including primary lesions and those secondary to other bone pathology. Cancer 61:2291–2304
Mirra JH (1989) Cysts and cystic-like lesions of bone. In: Mirra JH (ed) Bone tumors: clinical, radiologic, and pathologic correlations. Lea & Febiger, Philadelphia, pp 1233–1334
Munk PL, Helms CA, Holt RG, Johnson J, Steinbach L, Neumann C (1989) MR imaging of aneurysmal bone cysts. AJR 153:99–101
Petrik PK, Findlay JM, Sherlock RA (1993) Aneurysmal cyst, bone type, primary in artery. Am J Surg Pathol 17:1062–1066
Rodriguez-Peralto JL, Lopez-Barea F, Sanchez-Herrera S, Atienza M (1994) Primary aneurysmal cyst of soft tissues (extraosseous aneurysmal cyst). Am J Surg Pathol 18:632–636
Ruiter DJ, Rijssel TG van, Velde EA van der (1977) Aneurysmal bone cysts: a clinicopathologic study of 105 cases. Cancer 39:2231–2239
Salm R, Sissons HA (1972) Giant-cell tumours of soft tissues. J Pathol 107-27-39
Steiner GC, Kantor EB (1977) Ultrastructure of aneurysmal bone cyst. Cancer 40:2967–2978
Tillman BP, Dahlin DC, Lipscomb PR, Stewart JR (1968) Aneurysmal bone cyst: analysis of ninety-five cases. Mayo Clin Proc 43:478–495
Vergel de Dios A, Bond JR, Shives TC, McLeod RA, Unni KK (1992) Aneurysmal bone cyst: a clinicopathologic study of 238 cases. Cancer 69:2921–2931
Vicandi B, López-Barea F, Sánchez-Herrera S, González-López J, González del Pino J (1987) Quiste óseo aneurismático primario: estudio clinicopatológico de 23 casos. Patología 20:19–26
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López-Barea, F., Burgos-Lizaldez, E., Rodríguez-Peralto, J.L. et al. Primary aneurysmal cyst of soft tissue. Vichows Archiv A Pathol Anat 428, 125–129 (1996). https://doi.org/10.1007/BF00193941
- Soft tissue
- Aneurysmal bone cyst
- Magnetic resonance imaging