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Antibodies to the second Epstein-Barr virus nuclear antigen in non-Hodgkin lymphomas

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Abstract

Human antibodies against the first and second Epstein-Barr virus encoded nuclear antigens (EBNA-1 and EBNA-2) were analysed by modified ELISA reaction on immunoblots: 5 out of 20 EBNA-1 positive, healthy donor sera reacted with the EBNA-2. Healthy EBV seronegatives contained no antibodies against EBNA-2. The antibodies against this EBNA-2 developed several months after acute EBV infections. Four out of 8 infectious mononucleosis sera failed to react EBNA-2 in the late stage. In the group of EBV seropositive patients with non-Hodgkin lymphoma, 14 out of 18 sera contained EBNA-2 antibodies.

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Correspondence to L. Gergely.

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Gergely, L., Czeglédy, J., Váczi, L. et al. Antibodies to the second Epstein-Barr virus nuclear antigen in non-Hodgkin lymphomas. Med Microbiol Immunol 176, 175–179 (1987). https://doi.org/10.1007/BF00193899

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Keywords

  • Lymphoma
  • Late Stage
  • Healthy Donor
  • Nuclear Antigen
  • Human Antibody