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Developmental profile of a fetuin-like glycoprotein in neocortex, cerebrospinal fluid and plasma of post-natal tammar wallaby (Macropus eugenii)

Summary

A fetuin-like glycoprotein (FLG) has been shown to be present in early cortical plate cells in the developing brain of the tammar wallaby (Macropus eugenii). The developmental sequence of the occurrence of glycoprotein-positive fibres and cells in the dorsolateral telencephalic wall from newborn to day 40 is described. The level of FLG in CSF (cerebrospinal fluid) and plasma of the tammar wallaby has also been measured during pouch life. The presence of FLG in early postnatal fibre systems and in some cells in the primordial plexiform layer, as well as in early cortical plate cells of the tammar is similar to that of fetuin in fetal brain in sheep, pig and cow, and α2HS glycoprotein in human fetal brain. The sequence of appearance of FLG-positive cells during neocortical development in the tammar is strikingly similar to that of a transient population of early cortical plate cells previously described in fetal cat and sheep cortex. During postnatal development, levels of FLG in tammar plasma and CSF follow a pattern different from that of other species. The developmental expression of all three related glycoproteins in their respective species is discussed.

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References

  1. Bergmann FH, Levine L, Spiro RG (1962) Fetuin: immunochemistry and quantitative estimation in serum. Biochim Biophys Acta 58:41–51

  2. Bottenstein JE, Skaper SD, Varon SS, Sato GH (1980) Selective survival of neurons from chick embryo sensory ganglionic dissociates utilizing serum-free supplemented medium. Exp Cell Res 125:183–190

  3. Cavanagh ME, Warren A (1985) The distribution of native albumin and foreign albumin injected into lateral ventricles of prenatal and neonatal rat forebrains. Anat Embryol 172:345–351

  4. Christie DL, Dziegielewska KM, Hill RM, Saunders NR (1987) Fetuin: the bovine homologue of human α2HS glycoprotein. FEBS Lett 214:45–49

  5. Dziegielewska KM, Saunders NR (1988) The development of the blood-brain barrier: proteins in fetal and neonatal CSF, their nature and origins. In: Meisami E, Timiras PS (eds) Handbook of Human Growth and Developmental Biology, vol 1. CRC Press, Boca Raton, Florida

  6. Dziegielewska KM, Evans CAN, Fossan G, Lorscheider FL, Malinowska DH, Møllgård K, Reynolds ML, Saunders NR, Wilkinson S (1980) Proteins in cerebrospinal fluid and plasma of fetal sheep during development. J Physiol 300:441–455

  7. Dziegielewska KM, Hinds LA, Sarantis MEP, Saunders NR, Tyndale-Biscoe CH (1986) Proteins in cerebrospinal fluid and plasma of the pouch young tammar wallaby (Macropus eugenii) during development. Comp Biochem Physiol 83 B:561–567

  8. Dziegielewska KM, Møllgård K, Reynolds ML, Saunders NR (1987) A fetuin-related glycoprotein (α2HS) in human embryonic and fetal development. Cell Tissue Res 248:33–41

  9. Dziegielewska KM, Brown WM, Casey S-J, Christie DL, Foreman RC, Hill RM, Saunders NR (1990) The complete cDNA and amino acid sequence of bovine fetuin. Its homology with α2HS glycoprotein and relation to other members of the cystatin superfamily. J Biol Chem 265:4354–4357

  10. Jones SE, Dziegielewska KM, Saunders NR, Christie DL, Sueiras-Diaz J, Szelke M (1988) Early cortical plate specific glycoprotein in a marsupial species belongs to the same family as fetuin and α2HS glycoprotein. FEBS Lett 236:411–414

  11. Kita T, Inoue A, Nakanishi S, Numa S (1979) Purification and characterization of the messenger RNA coding for bovine corticotropin β-lipotropin precursor. Eur J Biochem 93:213–220

  12. Lee C-C, Bowman BH, Yang F (1987) Human-α2HS-glycoprotein: the A and B chains with a connecting sequence are encoded by a single mRNA transcript. Proc Natl Acad Sci USA 84:4403–4407

  13. Luskin MB, Shatz CJ (1985) Studies of the earliest generated cells of the cat's visual cortex: cogeneration of the cells of the marginal zone and subplate. J Neurosci 5:1062–1075

  14. Mancini G, Carbonara AO, Heremans JF (1965) Immunochemical quantitation of antigens by single radial immunodiffusion. Int J Immunochem 2:235–254

  15. Marin-Padilla M (1978) Dual origin of mammalian neocortex and evolution of the cortical plate. Anat Embryol 152:109–126

  16. Marin-Padilla M (1988) Early ontogenesis of the human cerebral cortex. In: Peters A, Jones EG (eds) Cerebral Cortex Vol 7, Plenum Press, New York, pp 1–34

  17. Møllgård K, Reynolds ML, Jacobsen M, Dziegielewska KM, Saunders NR (1984) Differential immunocytochemical staining for fetuin and transferrin in the developing cortical plate. J Neurocytol 13:497–502

  18. Møllgård K, Dziegielewska KM, Saunders NR, Zakut H, Soreq H (1988) Synthesis and localisation of plasma proteins in the developing human brain: integrity of the fetal blood-brain barrier to endogenous proteins of hepatic origin. Dev Biol 128:207–221

  19. Noda M, Furutani Y, Takahashi H, Toyosato M, Hirose T, Inayama S, Nakanishi S, Numa S (1982) Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin. Nature 295:202–206

  20. Renfree MB, Holt AB, Green SW, Carr JP, Cheek DB (1982) Ontogeny of the brain in a marsupial (Macropus eugenii) throughout pouch life. Brain Behav Evol 20:57–71

  21. Reynolds ML (1987) Early development of the neocortex in Eutheria and Metatheria: differentiation and plasma protein distribution. PhD thesis, University of London

  22. Reynolds ML, Møllgård K (1985) The distribution of plasma proteins in the neocortex and early allocortex of the developing sheep brain. Anat Embryol 171:41–60

  23. Reynolds ML, Saunders NR (1988) Differentiation of the neocortex. In: Tyndale-Biscoe CH, Janssens PA (eds) The developing marsupial: models for biomedical research. Springer, Berlin Heidelberg, pp 101–116

  24. Reynolds ML, Cavanagh ME, Dziegielewska KM, Hinds LA, Saunders NR, Tyndale-Biscoe CH (1985) Postnatal development of the telencephalon of the tammar wallaby (Macropus eugenii). An accessible model of neocortical differentiation. Anat Embryol 173:81–94

  25. Reynolds ML, Sarantis MEP, Lorscheider FL, Saunders NR (1987) Fetuin as a marker of cortical plate cells in the fetal cow neocortex: a comparison of the distribution of fetuin, α2HS glycoprotein, α-fetoprotein and albumin during early development. Anat Embryol 175:355–363

  26. Reynolds ML, Habgood MD, Ward RA, Saunders NR (1990) Origin and fate of fetuin-containing neurons in the developing neocortex of the fetal sheep. Submitted to J. Neurosci

  27. Rizzino A, Shermann MI (1979) Development and differentiation of mouse blastocysts in serum-free medium. Exp Cell Res 121:221–233

  28. Saunders NR, Adam E, Reader M, Møllgård K (1989) Monodelphis domestica (grey short-tailed opossum): an accessible model for studies of early neocortical development. Anat Embryol 180:227–236

  29. Shatz CJ, Chun JJM, Luskin MB (1988) The role of the subplate in the development of the mammalian telencephalon. In: Peters A, Jones EG (eds) Cerebral cortex Vol 7, Plenum Press, New York, pp 35–58

  30. Yoshioka Y, Gejyo F, Marti T, Rickli EE, Burgi W, Offner GD, Troxler RF, Schmid K (1986) The complete amino acid sequence of the A-chain of human plasma α2HS-glycoprotein. J Biol Chem 261:1665–1676

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Correspondence to N. R. Saunders.

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Jones, S.E., Christie, D.L., Dziegielewska, K.M. et al. Developmental profile of a fetuin-like glycoprotein in neocortex, cerebrospinal fluid and plasma of post-natal tammar wallaby (Macropus eugenii). Anat Embryol 183, 313–320 (1991). https://doi.org/10.1007/BF00192218

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Key words

  • Brain development
  • Marsupial
  • Neocortex
  • Fetuin