Esophageal dysfunction in diabetes mellitus: is there a relation to clinical manifestation of neuropathy?
- 47 Downloads
In a prospective study, we evaluated 33 diabetic patients [type I (n = 8) and type II (n = 25)]. Esophageal motor functions were examined by registering clinical symptoms and by performing esophageal manometry. We also investigated peripheral and autonomic neuropathy. In diabetics, the lower and upper esophageal sphincter pressure and amplitudes of peristaltic waves were reduced. Compared with controls (n = 30), in diabetics the esophageal peristaltic velocity was reduced significantly, and the duration of contractions were decreased as well. Multipeaked waves were uncommon in diabetics, while non-propulsive contractions were seen more often. No correlation was found between esophageal dysfunction and peripheral or autonomic neuropathy. Some 60% of diabetics reported esophageal symptoms; however, no relationship between these symptoms and the extent of dysfunction in esophageal motility was found.
Key wordsDiabetes mellitus Esophageal motility Manometry Autonomic cardiac neuropathy Peripheral sensorimotor neuropathy
peripheral sensorimotor polyneuropathy
autonomic cardiac neuropathy
lower esophageal sphincter
upper esophageal sphincter
Unable to display preview. Download preview PDF.
- 3.Christensen J (1988) The enteric nervous system. In: Kumar D, Gastavsson S (eds) An illustrated guide to gastrointestinal motility. Wiley, Chichester, pp 9–31.Google Scholar
- 6.Cordt A, Tackmann W (1988) Die diabetische Neuropathie. Nervenheilkunde 7: 46–53.Google Scholar
- 17.Kiruma J (1989) Electrodiagnosis in diseases of nerve and muscle: principles and practice. FA Davis, Philadelphia.Google Scholar
- 19.Luft D (1986) Die Neuropathie des autonomen Nervensystems bei Diabetes mellitus. Int Welt 9: 118–129.Google Scholar
- 32.WHO Expert Committee on Diabetes Mellitus (1980) Second report. (WHO Technical Report Series 646) WHO, Geneva.Google Scholar
- 33.Zeuzem S (1990) Diabetes and Gastrointestinaltrakt. Inn Med 17: 20–24.Google Scholar