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Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 338, Issue 5, pp 489–496 | Cite as

Effect of the dopamine receptor agonist apomorphine on sensory input

  • Henry Szechtman
Article

Summary

The study examines the hypothesis that changes in behavioural responsiveness induced by apomorphine reflect an effect of the drug on visual, tactile, vestibular, or proprioceptive sensory input. Rats were injected with apomorphine (1.25 mg/kg) and administered a neurological examination in which stimuli from the different sensory modalities were tested for their ability to elicit a limb placing response. Results indicate that these sensory stimuli were equally effective in eliciting reflex placing reactions in saline-and apomorphine-treated rats. Thus, contrary to the hypothesis, apomorphine does not appear to affect the reception of visual, tactile, vestibular, or proprioceptive sensory input. Tests of equilibration (righting) induced by static tilt revealed a fractionated response under apomorphine (0.6–5 mg/kg). Since the response to tilt probably involves striatal integration of vestibular and proprioceptive input, it is suggested that apomorphine disrupts sensory or sensorimotor integration.

Key words

Dopamine Reflex reactions Limb placing Negative geotropism Tail suspension Fractionated equilibration response Tilt Vestibular system Striatum Sensorimotor integration Sequencing of movements Rats 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Henry Szechtman
    • 1
  1. 1.Department of Biomedical SciencesMcMaster UniversityHamiltonCanada

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