Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 343, Issue 4, pp 393–398 | Cite as

Effect of denervation on the neurogenic inflammation of the rat mandibular mucosa

  • Árpád Fazekas
  • Adrienne Györfi
  • Elek Pósch
  • Gábor Jakab
  • Zsolt Bártfai
  • László Rosivall


Effects of local exposure to capsaicin on the vascular permeability and blood flow were studied in the rat oral mucosa at days 2 and 14 after the unilateral transcection of the inferior alveolar nerve (IAN). The distribution of nerve fibers displaying substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactivity (IR) in the mandibular mucosa was also assessed.

While the capsaicin-induced augmentation in vascular permeability was about 50% (P < 0.05) higher on the intact side (at both days 2 and 14) than on the denervated side, no difference in blood flow elevation was seen between the two sides. Transection of IAN caused only a slight reduction in the density of SP- and CGRP-IR fibers in the mucosa.

It is concluded that in addition to the IAN fibers the mandibular mucosa examined also seems to be supplied by other sensory fibers. The presence of accessory trigeminal branches was also supported by immunohistochemical studies.

Key words

Mandibular mucosa Local capsaicin irritation Neurogen inflammation Immunohistochemistry Denervation 


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Árpád Fazekas
    • 1
  • Adrienne Györfi
    • 2
  • Elek Pósch
    • 2
  • Gábor Jakab
    • 3
  • Zsolt Bártfai
    • 4
  • László Rosivall
    • 2
  1. 1.Department of Conservative DentistrySemmelweis University of MedicineBudapestHungary
  2. 2.Department of PathophysiologySemmelweis University of MedicineBudapestHungary
  3. 3.Department of NeurologySemmelweis University of MedicineBudapestHungary
  4. 4.II. Department of AnatomySemmelweis University of MedicineBudapestHungary

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