Abstract
Laboratory investigations of virus isolation and serum antibodies in a Mediterranean country (Italy) demonstrated that influenza A and B viruses, and often both, circulated every winter in Italy.
The winter 1987/88 was characterized by a low level of influenza activity, as shown by the limited number (47) of influenza virus isolates, the majority of which (61%) belonged to the influenza B type. In contrast, the 1988/89 influenza season was exclusively associated with the circulation of influenza type A viruses. The A(HlH1) subtype was largely predominant (97%), as compared to the low incidence of the A(H3N2) subtype (3%). During the 1989/90 winter a cocirculation of A and B influenza viruses was observed, A(H3N2) strains being responsible for 96% of the virologically confirmed cases.
Antigenic analysis of the virus isolates showed some antigenic variation in influenza A viruses of both HlN1 and H3N2 subtypes, whilst antigenic stability was found among the influenza B virus isolates.
Overall, the above virological findings correlate with the data concerning the pattern of influenza virus circulation in Northern Europe and the UK during the three years surveyed.
The results of serum antibody surveys conducted in each post-epidemic period are also reported.
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References
AilingD.W., BlackwelderW.C. and Stuart-HarrisC.H. (1981): A study of excess mortality during influenza epidemics in the United States, 1968–1976 - Am. J. Epid. 113: 30–43.
ChakravertyP., CunninghamP., ShenG.Z. and PereiraM.S. (1986): Influenza in the United Kingdom 1982–1985- J. Hyg. Camb. 97: 347–358.
ChoiK. and ThackerS.B. (1981): An evaluation of influenza mortality surveillance, 1962–1979 - Am. J. Epid. 113: 227–235.
CliffordR.E., SmithJ.W.G., TillettH.E. and WherryP.J. (1977): Excess mortality associated with influenza in England and Wales - Int. J. Epidemiol. 6: 115–128.
GlezenW.P. (1982): Serious morbidity and mortality associated with influenza epidemics - Epidemiol. Rev. 4: 25–44.
HammondG.W. and CheangM. (1984): Absenteeism among hospital staff during an influenza epidemic -Can. Med. Assoc. J. 131: 449–455.
HobsonD., CurryR.L., BeareA.S. and Ward-GardnerA. (1972): The role of serum haemagglutination-inhibitory antibody in protection against challenge infection with A2 and B viruses - J. Hyg. Camb. 70: 767–773.
ManciniG., Arangio RuizG., CampitelliL., CastrucciM.R., DianaL., DonatelliI. and RuggieriA. (1988): Surveillance of influenza A and B viruses in Italy between 1984 and 1987 - Eur. J. Epidemiol 4: 445–450.
PereiraM., AssoadF.A. and DelonP.J. (1978): Influenza surveillance. Bulletin of the World Health Organization 56: 193–203.
PyhäläR., KleemolaM. and VisarorpiR. (1984): The HI test modified by ether treatment in the sero-epidemiological surveillance of influenza B - J. Hyg. Camb. 94: 341–348.
SaitouN. and NeiM. (1986): Polymorphism and evolution of influenza A virus genes - Mol. Biol. Evol. 3: 57–74.
TillettH.E. and SpencerI.L. (1982): Influenza surveillance in England and Wales using routine statistics - J. Hyg. Camb. 88: 83–94.
U.S. Department of Health and Human Services. Concepts and Procedures for Laboratory-Based Influenza Surveillance (1982). Atlanta - Georgia.
WebsterR.G., LaverW.G. and AirG.M. (1983): Antigenic variation among type A influenza viruses. In: Palese P., Kingsbury D.W. (eds): “Genetics of Influenza viruses” New York: Springer-Verlag, pp. 127–168.
WHO Wkly Epidemiology Record (1988): 63 (N. 44): 333–340 - Geneve, Switzerland.
WHO Wkly Epidemiology Record (1989): 64 (N. 8): 53–60- Geneve, Switzerland.
WHO Wkly Epidemiology Record (1989): 64 (N. 44): 337–344 - Geneve, Switzerland.
WHO Wkly Epidemiology Record (1989): 64 (N. 48): 369–376 - Geneve, Switzerland.
WHO Wkly Epidemiology Record (1989): 64 (N. 50): 385–392 - Geneve, Switzerland.
WHO Wkly Epidemiology Record (1989): 64 (N. 51–52): 393–400 - Geneve, Switzerland.
WHO Wkly Epidemiology Record (1990): 65 (N. 6): 37–44- Geneve, Switzerland.
WHO Wkly Epidemiology Record (1990): 65 (N. 8): 53–60- Geneve, Switzerland.
WHO Wkly Epidemiology Record (1990): 65 (N. 11): 77–84 - Geneve, Switzerland.
WileyD.C., WilsonJ.A. and SkehelJ.J. (1981): Structural identification of the antibody binding sites of HongKong influenza haemagglutinin and their involvement in antigenic variation - Nature 289:373–378.
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Donateli, I., Campitelli, L., Ruggieri, A. et al. Concurrent antigenic analysis of recent epidemic influenza A and B viruses and quantitation of antibodies in population serosurveys in Italy. Eur J Epidemiol 9, 241–250 (1993). https://doi.org/10.1007/BF00146258
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DOI: https://doi.org/10.1007/BF00146258