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Bacterial Genotoxins as the Interphase Between DNA Damage and Immune Response

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Microbial Toxins

Part of the book series: Toxinology ((TOXI))

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Abstract

Bacterial genotoxins are a class of molecules that have the ability to enter the nucleus of a host cell and cause DNA damage by introducing single- and double-strand DNA breaks, leading to various effects, including activation of DNA damage response, senescence, apoptosis, and genetic aberrations. There is emerging evidence for an intricate connection between the DNA damage response and immunity, and it is becoming increasingly clear that bacterial genotoxins can act as potent immunomodulatory factors, which bacteria use in order to tailor the host immune response. This chapter will review some of the basic structural and functional characteristics of bacterial genotoxins and the internalization pathway used to reach the host DNA within the nuclear compartment. Special focus will be given to the connection between the genotoxin-induced DNA damage response and modulation of the host immune responses. Since it is not entirely clear what is the evolutionary advantage for bacteria that express these effectors, the possibility that they might play a role in influencing host immune response in order to promote stealth invasion and establishment of persistent infections will be explored.

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Authors and Affiliations

  1. Cell and Molecular Biology Department, Karolinska Institutet, Stockholm, Sweden

    Océane C. B. Martin, Teresa Frisan & Boris Mihaljevic

Authors
  1. Océane C. B. Martin
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  2. Teresa Frisan
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  3. Boris Mihaljevic
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Correspondence to Océane C. B. Martin , Teresa Frisan or Boris Mihaljevic .

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Editors and Affiliations

  1. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    P. Gopalakrishnakone

  2. Biology Department, Wilson College , Chambersburg, Pennsylvania, USA

    Brad Stiles

  3. Department of Biochemistry, School of Medicine and Instituto Clodomiro Picado, Faculty of Microbiology, University of Costa Rica , San Pedro de Montes de Oca, Costa Rica

    Alberto Alape-Girón

  4. Département de pathologie et microbiologie, Faculté de médecine vétérinaire, Université de Montréal , Saint-Hyacinthe, Canada

    J. Daniel Dubreuil

  5. College of Pharmacy, Roseman University of Health Sciences, Henderson, Nevada, USA

    Manas Mandal

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Martin, O.C.B., Frisan, T., Mihaljevic, B. (2016). Bacterial Genotoxins as the Interphase Between DNA Damage and Immune Response. In: Gopalakrishnakone, P., Stiles, B., Alape-Girón, A., Dubreuil, J., Mandal, M. (eds) Microbial Toxins. Toxinology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6725-6_14-1

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  • DOI: https://doi.org/10.1007/978-94-007-6725-6_14-1

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