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Dermal and Transdermal Delivery

  • Living reference work entry
  • First Online:
Encyclopedia of Nanotechnology

Synonyms

Dermal delivery – dermal absorption, skin penetration, cutaneous delivery, skin delivery

Transdermal delivery – percutaneous absorption, transdermal permeation, transcutaneous delivery

Definition

Dermal delivery refers to the process of mass transport of active ingredients applied on the skin to various skin strata.

Transdermal delivery refers to the entire process of mass transport of substances applied on the skin surface and includes their absorption by each layer of the skin, their uptake by microcirculation of the skin, and distribution in the systemic circulation.

Introduction

History of Therapeutic Systems Applied on the Skin

The history of skin application of therapeutic substances goes back to ancient times. Numerous carriers, including conventional semisolid bases (creams, gels, ointments), matrix systems (clays, polymers), and liquid systems (solutions, emulsions, suspensions), are being used for cutaneous application of therapeutics for centuries. Transdermal...

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Author information

Authors and Affiliations

  1. Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Ave., Houston, TX, 77030, USA

    Biana Godin

  2. Institute of Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

    Elka Touitou

Authors
  1. Biana Godin
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  2. Elka Touitou
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Corresponding author

Correspondence to Biana Godin .

Editor information

Editors and Affiliations

  1. Biomimetics (NLB²), Ohio State University Nanoprobe Lab. for Bio- & Nanotechnology, Columbus, Ohio, USA

    Bharat Bhushan

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Godin, B., Touitou, E. (2015). Dermal and Transdermal Delivery. In: Bhushan, B. (eds) Encyclopedia of Nanotechnology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6178-0_81-2

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  • DOI: https://doi.org/10.1007/978-94-007-6178-0_81-2

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  • Online ISBN: 978-94-007-6178-0

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