Definition
Focal lesions are circumscribed areas of injury to brain tissue following brain injury. Such lesions may be created when an object penetrates the skull and directly injures an area of the brain. In closed head injury, such lesions are usually associated with vascular damage, such as contusions or hemorrhages.
Current Knowledge
In contrast to diffuse brain injuries, such as diffuse axonal injury, focal lesions and focal contusions can result in isolated deficits of cognition, speech, sensory, and language functions depending on location. Contusions, or bruises, typically form in gray matter where there is a higher degree of vasculature than in white matter. Hemorrhages and hematomas may be subarachnoid (SAH, between the dura and the skull), subdural (SDH, between dura and brain), epidural (EDH, associated with dural tears), or intracerebral (ICH, within brain tissue). Multiple focal lesions or contusions may result from diffuse vasculopathic processes that can cause a series...
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References and Readings
Ammerman, J. M., et al. (2006). Traumatic intracranial hemorrhage. In R. W. Evans (Ed.), Neurology and trauma (2nd ed., pp. 156–166). Oxford: Oxford University Press.
Bigler, E. D. (2001). Distinguished Neuropsychologist Award Lecture 1999. The lesion(s) in traumatic brain injury: implications for clinical neuropsychology. Archives of Clinical Neuropsychology, 16, 95–131.
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Rush, B. (2016). Focal Lesion, Contusion. In: Kreutzer, J., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-56782-2_242-2
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DOI: https://doi.org/10.1007/978-3-319-56782-2_242-2
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