Living Reference Work Entry

Endocrinology of the Testis and Male Reproduction

Part of the series Endocrinology pp 1-36

Date: Latest Version

GnRH Action

GnRH Signaling
  • Kathryn L. GarnerAffiliated withLaboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol
  • , Krasimira Tsaneva-AtanasovaAffiliated withDepartment of Mathematics, College of Engineering, Mathematics and Physical Sciences, University of ExeterEPSRC Centre for Predictive Modelling in Healthcare, University of Exeter
  • , Craig A. McArdleAffiliated withLaboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol Email author 

Abstract

Gonadotropin-releasing hormone (GnRH) mediates central control of reproductive function by activation of G-protein-coupled receptors on pituitary gonadotropes. These Gq-coupled receptors mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone and follicle-stimulating hormone and also chronic regulation of the synthesis of these gonadotropin hormones. GnRH is secreted in brief pulses and GnRH effects on its target cells are dependent upon the characteristics of these pulses. Here we provide an overview of GnRH receptors and their signaling network, emphasizing novel and atypical functional features of GnRH signaling, and mechanisms mediating pulsatile hormone signaling.

Keywords

GnRH GnRH receptors G-proteins Phospholipase C ERK NFAT MAPK