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Cellular Ecophysiology of Microbe pp 1–23Cite as

Transcriptional Regulation of Hydrocarbon Efflux Pump Expression in Bacteria

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Part of the book series: Handbook of Hydrocarbon and Lipid Microbiology ((HHLM))

Abstract

Efflux pumps were found to be the most efficient mechanism of hydrocarbon tolerance in several bacterial strains resistant to solvents and other toxic chemicals. This involves an energy-dependent process that ensures the active removal of toxic compounds from the bacterial cytoplasm to the external medium. In order to achieve the maximal response of the process, regulatory networks of RND efflux pumps (resistance-nodulation-cell division family of bacterial transporters) are complex and modulated by the simultaneous coordination of many transcription factors in response to perturbations and cellular states. Several studies in the literature report the identification and molecular characterization of regulatory genes of RND efflux pumps, acting as global or specific regulators, activating or repressing transcription. In this sense, the main objective of this chapter is to provide a general view of the regulatory networks used by bacteria to modulate the response to toxic hydrocarbons mediated by efflux pumps. We also explore conceptual properties that remain conserved in different regulatory systems and outline common principles of RND regulation in gram-negative bacteria.

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Acknowledgments

This work was supported by the National Counsel of Technological and Scientific Development (CNPq 472893/2013-0 and 441833/2014-4) and by the Sao Paulo State Foundation (FAPESP, grant number 2015/04309-1 and 2012/21922-8). CAW and LFA are beneficiaries of CAPES fellowship. Authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Departamento de Biologia Celular, FMRP – Universityof São Paulo, Ribeirão Preto, SP, Brazil

    Cauã Antunes Westmann & Rafael Silva-Rocha

  2. Departamento de Biologia, FFCLRP – Universityof São Paulo, Av. Bandeirantes, 3.900, 14049-901, Ribeirão Preto, SP, Brazil

    Luana de Fátima Alves, Tiago Cabral Borelli & María-Eugenia Guazzaroni

  3. Departamento de Bioquímica e Imunologia, FMRP – Universityof São Paulo, Ribeirão Preto, SP, Brazil

    Luana de Fátima Alves

  4. Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes, 3.900, CEP: 14049-901, Ribeirão Preto, São Paulo, Brazil

    María-Eugenia Guazzaroni

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  2. Luana de Fátima Alves
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Correspondence to María-Eugenia Guazzaroni .

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  1. Consejo Superior de Investigaciones, Estacion Experimental del Zaidin, Granada, Spain

    Tino Krell

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Westmann, C.A., de Fátima Alves, L., Borelli, T.C., Silva-Rocha, R., Guazzaroni, ME. (2017). Transcriptional Regulation of Hydrocarbon Efflux Pump Expression in Bacteria. In: Krell, T. (eds) Cellular Ecophysiology of Microbe. Handbook of Hydrocarbon and Lipid Microbiology . Springer, Cham. https://doi.org/10.1007/978-3-319-20796-4_4-2

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  1. Latest

    Transcriptional Regulation of Hydrocarbon Efflux Pump Expression in Bacteria
    Published:
    25 March 2017

    DOI: https://doi.org/10.1007/978-3-319-20796-4_4-2

  2. Original

    Transcriptional Regulation of Hydrocarbon Efflux Pump Expression in Bacteria
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    29 December 2016

    DOI: https://doi.org/10.1007/978-3-319-20796-4_4-1

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