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Daily Routine in Cosmetic Dermatology pp 1–16Cite as

Retinoids

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Abstract

Retinoid includes all natural or synthetic compounds based in vitamin A (Vit. A) similar activity, thereby has the ability to activate nuclear retinoid receptors. Through the discovery of nuclear receptors for retinoic acid, greater understanding of mechanism of action of these compounds was achieved. Such advance allows also the possibility of development of molecules with specific roles in various pathological affections that are the cause of many diseases.

These receptors are coupled to certain regions of DNA that are responsive to activation by retinol and/or retinoic acid. Subsequently, the message is transcribed (messenger RNA) to ribosomes, where proteins are synthesized. Therefore, they end up acting at the cellular differentiation, embryonic morphogenesis, and carcinogenesis.

Retinoids are classified into generations. The first generation: retinoic acid (RA), tretinoin or acid vitamin A, alitretinoin (9 cis-retinoic acid), and isotretinoin (13 cis-retinoic acid). They are all isomers and naturally occur in the organism.

Acitretin and its precursor etretinate are the second-generation retinoids.

The more recent third generation is represented by adapalene, tazarotene, motretinide, and arotinoides.

Retinoids have a large number of indications. According to the indication, their use can be topical or systemic. Their benefits range from anti-inflammatory action, immunomodulatory effects, and more recently of photoaging.

A huge list of possible adverse effects must be known in order to minimize the risk. They are essentially dose dependent.

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Authors and Affiliations

  1. Instituto de Dermatologia Professor Rubem David Azulay/Santa Casa da Misericórdia, Rio de Janeiro, Brazil

    David Rubem Azulay & Dâmia Leal Vendramini

Authors
  1. David Rubem Azulay
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  2. Dâmia Leal Vendramini
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Correspondence to David Rubem Azulay .

Editor information

Editors and Affiliations

  1. Universidade Federal Fluminense, Niterói, São Paulo, Brazil

    Maria Claudia Almeida Issa

  2. Lexbios Medica S/S, São Paulo, São Paulo, Brazil

    Bhertha Tamura

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© 2016 Springer International Publishing Switzerland

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Azulay, D.R., Vendramini, D.L. (2016). Retinoids. In: Issa, M., Tamura, B. (eds) Daily Routine in Cosmetic Dermatology. Clinical Approaches and Procedures in Cosmetic Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-20250-1_15-1

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  • DOI: https://doi.org/10.1007/978-3-319-20250-1_15-1

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  • Publisher Name: Springer, Cham

  • Online ISBN: 978-3-319-20250-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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