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4-Hydroxynonenal in the Physiology and Pathology of Malaria

  • Living reference work entry
  • First Online:
Encyclopedia of Malaria

  • 426 Accesses

Synonyms

HNE; Lipid peroxidation

Definition

Oxidative stress is the consequence of imbalance between prooxidative reactions and antioxidative responses in the cell. In the pathophysiology of malaria, oxidative stress represents an important aspect of the host–parasite relationship which plays a key role in many fatal end points of the disease (reviewed in Percario et al. 2012; Becker et al. 2004). Alteration in redox metabolism may be important in two ways: Prooxidative reactions are central in the host response to successfully combat malaria infection. In malaria patients, plasma lipid peroxides are increased (Das et al. 1990) and red blood cells (RBCs) show increased lipid peroxidation and decreased antioxidative defense parameters (Das and Nanda 1999). On the other hand, overwhelming oxidative stress seems to be dangerous for the infected host cell and contribute to severe malaria forms with potentially fatal outcome.

Oxidative stress interferes with many cellular functions, such as...

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Abbreviations

4-HNE:

4-Hydroxynonenal

DC:

Dendritic cell

DHN:

Dihydroxynonene

GM-CSF:

Granulocyte–monocyte colony-stimulating factor

GSH:

Reduced glutathione

HETE:

Hydroxyeicosatetraenoic acid, hydroxylated arachidonic acid

HNA:

Hydroxynonenoic acid

HODE:

Hydroxyoctadecadienoic acid, hydroxylated linoleic acid

NF-kB:

Nuclear factor kappa-light-chain-enhancer of activated B cells

npRBC:

Nonparasitized RBC

P. falciparum :

Plasmodium falciparum

PUFA:

Polyunsaturated fatty acid

RB:

Residual body, natural hemozoin

RBC:

Red blood cell, erythrocyte

ROS:

Reactive oxygen species, oxygen radicals

Tf:

Transferrin

TLR:

Toll-like receptor

WBC:

White blood cell

PKC:

Protein kinase C

CD80, CD83, CD 40, CD1a, CD11c/18:

Surface antigens involved in antigen presentation

CD54:

ICAM-1, intercellular adherance molecule-1

MHC II:

Main histocompatibility complex class II , antigen presenting surface molecule

p53:

Transcription factor protein p53, cell cycle regulator

Epo-R:

Erythropoietin receptor

IL3-R:

Interleukin 3-receptor

TfR:

Transferrin receptor

SCFR:

Stem cell factor receptor

HZ:

Hemozoin, malarial pigment

CTRL:

Control

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Authors and Affiliations

  1. Department of Oncology, University of Torino, Torino, Italy

    Evelin Schwarzer, Paolo Arese & Oleksii Skorokhod

Authors
  1. Evelin Schwarzer
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  2. Paolo Arese
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  3. Oleksii Skorokhod
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Corresponding author

Correspondence to Evelin Schwarzer .

Editor information

Editors and Affiliations

  1. Heswall, United Kingdom

    Marcel Hommel

  2. Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany

    Peter G. Kremsner

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Schwarzer, E., Arese, P., Skorokhod, O. (2013). 4-Hydroxynonenal in the Physiology and Pathology of Malaria. In: Hommel, M., Kremsner, P. (eds) Encyclopedia of Malaria. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8757-9_96-1

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  • DOI: https://doi.org/10.1007/978-1-4614-8757-9_96-1

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