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Encyclopedia of Behavioral Medicine pp 1–3Cite as

Hepatitis C and Cognitive Functioning

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Synonyms

Cirrhosis of the liver; Liver disease; Viral hepatitis

Definition

Hepatitis is the inflammation of the liver. The hepatitis C virus (HCV) infects and damages the liver, affecting the organ’s ability to metabolize, detoxify, and help with digestion functions. The infection can lead to acute and chronic hepatitis, cirrhosis, hepatocellular carcinoma, neurocognitive impairment, and potential decline in daily functioning. An estimated 3.2 million people are infected with HCV in the United States, with approximately 30,000 new infections reported each year.

Description

Etiology

HCV is spread when the blood of an infected host enters the body of a non-infected person. Most commonly this occurs through sharing contaminated intravenous drug paraphernalia and blood transfusions or organ transplants that took place before 1992. HCV replicates in the peripheral blood mononuclear cells and bone marrow. The immune system is composed of white bloods cells that help fight infection....

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References and Further Readings

  • Catie, J. E., Letendra, S. L., Woods, S. P., Barakat, F., Perry, W., Cherner, M., Umlauf, A., Franklin, D., Heaton, R. K., Hassanein, T., & Grant, I. (2014). Persistent neurocognitive decline in a clinical sample of hepatitis C virus-infected persons receive interferon and ribavirin treatment. Journal of Neurovirology, 20, 561–570.

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  • Kohli, A., Shaffer, A., Sherman, A., & Kottilil, S. (2014). Treatment of hepatitis C: A systematic review. JAMA, 312(6), 631–640.

    Article  CAS  PubMed  Google Scholar 

  • McAndrews, M. P., Farcnik, K., Carlen, P., Damyanovich, A., Mrkonjic, M., Jones, S., & Heathcote, E. J. (2005). Prevalence and significance of neurocognitive dysfunction in hepatitis C in the absence of correlated risk factors. Hepatology, 41(4), 801–808. doi:10.1002/hep.20635.

    Article  PubMed  Google Scholar 

  • Sakamoto, M., Woords, S. P., Kolessar, M., Kriz, D., Anderson, J. R., Olaverria, H., Sasaki, A., Chang, M., Flora, K. D., Loftis, J. M., & Huckans, M. (2013). Protective effects of higher cognitive reserve for neuropsychological and daily functioning among individuals infected with hepatitis C. Journal of Neurovirology, 19, 442–451.

    Article  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. VA Portland Health Care System, Portland, OR, USA

    Supria K. Gill, Michael I. Demidenko & Travis I. Lovejoy

  2. Department of Psychiatry and School of Public Health, Oregon Health & Science University, Portland, Portland, OR, USA

    Travis I. Lovejoy

  3. Palo Alto University, Palo Alto, CA, USA

    Supria K. Gill

Authors
  1. Supria K. Gill
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  2. Michael I. Demidenko
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  3. Travis I. Lovejoy
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Corresponding author

Correspondence to Supria K. Gill .

Editor information

Editors and Affiliations

  1. University of Miami School of Medicine, Miami, Florida, USA

    Marc Gellman

  2. Campbell University School of Pharmacy, Buies Creek, North Carolina, USA

    J. Rick Turner

Section Editor information

  1. Department of Psychology, University of Miami, 5665 Ponce de Leon Blvd, 33124-0751, Coral Gables, FL, USA

    Steven A. Safren

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Gill, S.K., Demidenko, M.I., Lovejoy, T.I. (2017). Hepatitis C and Cognitive Functioning. In: Gellman, M., Turner, J. (eds) Encyclopedia of Behavioral Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6439-6_101941-2

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  • DOI: https://doi.org/10.1007/978-1-4614-6439-6_101941-2

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6439-6

  • Online ISBN: 978-1-4614-6439-6

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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Chapter history

  1. Latest

    Hepatitis C and Cognitive Functioning
    Published:
    06 April 2017

    DOI: https://doi.org/10.1007/978-1-4614-6439-6_101941-2

  2. Original

    Hepatitis C and Cognitive Functioning
    Published:
    18 January 2017

    DOI: https://doi.org/10.1007/978-1-4614-6439-6_101941-1

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