Synopsis
The success of plasmids as stably inherited, autonomously replicating units depends on control circuits that ensure that positive events such as replication occur efficiently at a set average frequency and that the genetic load carried by the plasmid is at minimal metabolic cost to the host. While selective pressure has ensured that natural plasmids do achieve this, the wish to exploit plasmids or interfere with their survival mechanisms for biotechnological applications means that we need to understand the critical features that are needed for success. Mathematical modeling of the intracellular control circuits can help to explore different systems and to distinguish between key parameters and those whose variation will have little effect on the system. The relatively low complexity of plasmids makes them ideal systems to model and they also provide suitable systems to test prediction from the models. In the past, plasmid modeling has particularly focused on the ColE1 and R1...
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Stekel, D.J. (2014). Modeling Plasmid Regulatory Systems. In: Bell, E. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6436-5_573-4
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DOI: https://doi.org/10.1007/978-1-4614-6436-5_573-4
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Publisher Name: Springer, New York, NY
Online ISBN: 978-1-4614-6436-5
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