Synopsis
Gene expression describes the flow of genetically encoded information from DNA to its intermediary form, mRNA, and its functional form, protein. In eukaryotes, mRNAs are co-transcriptionally highly processed from a precursor mRNA or pre-mRNA to a mature mRNA. To form mature mRNAs, the pre-mRNA’s 5′ end is capped, its coding regions are joined together during a process called pre-mRNA splicing, and its 3′ end is cleaved and appended with a poly(A) tail. By modifying pre-mRNAs, the cell is afforded multiple opportunities for regulatory control in the diversity and levels of an mRNA prior to its translation into protein.
Introduction
For all organisms, the expression of genes from DNA to functional protein requires first the transfer of information to a transient messenger RNA molecule known as mRNA. In prokaryotes, mRNAs are typically direct copies...
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References
Bentley DL (2005) Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors. Curr Opin Cell Biol 17(3):251–256
Black DL (2003) Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem 72:291–336
Buratowski S (2009) Progression through the RNA polymerase II CTD cycle. Mol Cell 36(4):541–546
Chen M, Manley JL (2009) Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol 10(11):741–754
Di Giammartino DC, Nishida K, Manley JL (2011) Mechanisms and consequences of alternative polyadenylation. Mol Cell 43(6):853–866
Egloff S, Murphy S (2008) Cracking the RNA polymerase II CTD code. Trends Genet 24(6):280–288
Licatalosi DD, Darnell RB (2010) RNA processing and its regulation: global insights into biological networks. Nat Rev Genet 11(1):75–87
Luco RF et al (2011) Epigenetics in alternative pre-mRNA splicing. Cell 144(1):16–26
Mandel CR, Bai Y, Tong L (2008) Protein factors in pre-mRNA 3′-end processing. Cell Mol Life Sci CMLS 65(7–8):1099–1122
Millevoi S, Vagner S (2010) Molecular mechanisms of eukaryotic pre-mRNA 3′ end processing regulation. Nucleic Acids Res 38(9):2757–2774
Moore MJ, Proudfoot NJ (2009) Pre-mRNA processing reaches back to transcription and ahead to translation. Cell 136(4):688–700
Proudfoot NJ, Furger A, Dye MJ (2002) Integrating mRNA Processing with Transcription. Cell 108(4):501–512
Wahl MC, Will CL, Lührmann R (2009) The spliceosome: design principles of a dynamic RNP machine. Cell 136(4):701–718
Wang Z, Burge CB (2008) Splicing regulation: from a parts list of regulatory elements to an integrated splicing code. RNA 14(5):802–813
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Marvin, B., Inada, M. (2014). Co-transcriptional mRNA Processing in Eukaryotes. In: Bell, E. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6436-5_41-4
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DOI: https://doi.org/10.1007/978-1-4614-6436-5_41-4
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Publisher Name: Springer, New York, NY
Online ISBN: 978-1-4614-6436-5
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