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GABA Neurotransmission: An Overview

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Handbook of Neurochemistry and Molecular Neurobiology

Abstract:

GABA neurotransmission involves biosynthesis and metabolic degradation of GABA, its stimulus-coupled release and receptor interaction, as well as inactivation by high-affinity transport systems in neuronal and astrocytic plasma membranes. These entities are summarized to provide the reader with information about the fundamental properties of these processes.

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Abbreviations

AOAA:

amino-oxyacetic acid

BGT-1:

betaine-GABA transporter-1

CACA:

cis-4-aminocrotonic acid

CAMP:

cis-2-(aminomethyl)cyclopropane-1-carboxylic acid

CIT:

citrate

CNS:

central nervous system

EF-1502:

N-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-4-(methylamino)-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol

exo-THPO:

4-amino-4,5,6,7-tetrahydro-1,2-benzo[d]isoxazol-3-ol

GABA:

gamma-aminobutyric acid

GABA-T:

GABA-transaminase

GAD:

glutamic acid decarboxylase

GAT 1–4:

GABA transporters 1–4

Glu:

glutamate

OAA:

oxaloacetate

PAG:

phosphate activated glutaminase

SSA:

succinate semialdehyde

SUC:

succinate

TCA:

tricarboxylic acid

THIP:

4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol

THPO:

4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol

2OG:

2-oxoglutarate

3-APPA:

3-aminopropylphosphonic acid

3-APMPA:

3-aminopropyl(methyl)phosphinic acid

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Authors
  1. A. Schousboe
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  2. H. S. Waagepetersen
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Editors and Affiliations

  1. Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, 10962, 140 Old Orangeburg Road, Orangeburg, New York, USA

    Abel Lajtha (Director) (Director)

  2. Institute of Experimental Medicine, Hungarian Academy of Sciences, 43, H-1083 Budapest, Szigony, Hungary

    E. Sylvester Vizi

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Schousboe, A., Waagepetersen, H.S. (2008). GABA Neurotransmission: An Overview. In: Lajtha, A., Vizi, E.S. (eds) Handbook of Neurochemistry and Molecular Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-30382-6_9

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