Abstract
Target validation in health and disease integrates the modulation of a certain molecular target with an expected biological/biochemical/physiological or pathophysiological response or effect. The current state-of-the-art in target validation requires the interface of multiple complementary approaches and technologies to define the mechanistic connectivity between a molecular target and underlying micro- and macrobiotic processes. Target validation also represents the basis for “drug target validation” with focus on therapeutic applications. The concepts of “target validation” and “drug-based therapeutic intervention” continue to coevolve as new classes of therapeutic agents and delivery systems emerge and enable us to target or modulate previously inaccessible molecular entities.
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Plata-Salamán, C.R., Ilyin, S.E. (2007). Considerations for Target Validation and Industrial Approaches. In: Sioud, M. (eds) Target Discovery and Validation Reviews and Protocols. Methods in Molecular Biology™, vol 361. Humana Press. https://doi.org/10.1385/1-59745-208-4:299
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DOI: https://doi.org/10.1385/1-59745-208-4:299
Publisher Name: Humana Press
Print ISBN: 978-1-58829-890-4
Online ISBN: 978-1-59745-208-3
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