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Antibody-Drug Conjugates pp 117–131Cite as

Pharmacokinetics and ADME Characterizations of Antibody–Drug Conjugates

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1045))

Abstract

Pharmacokinetic and absorption, distribution, metabolism, and excretion (ADME) characterization of antibody–drug conjugates (ADCs) reflects the dynamic interactions between the biological system and ADC, and provides critical assessments in lead selection, optimization, and clinical development. Understanding the pharmacokinetics (PK), ADME properties and consequently the pharmacokinetic-pharmacodynamic properties of ADCs is critical for their successful development. This chapter discusses the PK properties of ADCs, types of PK and ADME studies in supporting different stages of development, general design of PK/ADME studies with a focus on ADC-specific characteristics, and interpretation of PK parameters.

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Acknowledgements

The authors would like to thank PKPD colleagues for their constructive input and careful review of this manuscript.

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Authors and Affiliations

  1. Early Development Pharmacokinetics and Pharmacodynamics, Genentech Inc., South San Francisco, CA, USA

    Kedan Lin & Ben-Quan Shen

  2. Drug Metabolism and Pharmacokinetics, UCB Celltech Slough, Berkshire, UK

    Jay Tibbitts

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  1. Kedan Lin
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  2. Jay Tibbitts
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  1. Lonza Ltd, Visp, Switzerland

    Laurent Ducry

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Lin, K., Tibbitts, J., Shen, BQ. (2013). Pharmacokinetics and ADME Characterizations of Antibody–Drug Conjugates. In: Ducry, L. (eds) Antibody-Drug Conjugates. Methods in Molecular Biology, vol 1045. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-541-5_7

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  • DOI: https://doi.org/10.1007/978-1-62703-541-5_7

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