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Yeast Systems Biology: The Challenge of Eukaryotic Complexity

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Yeast Systems Biology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 759))

Abstract

In this chapter, we present an up-to-date view of the optimal characteristics of the yeast Saccharomyces cerevisiae as a model eukaryote for systems biology studies, with main molecular mechanisms, biological networks, and sub-cellular organization essentially conserved in all eukaryotes, derived from a complex common ancestor. The existence of advanced tools for molecular studies together with high-throughput experimental and computational methods, most of them being implemented and validated in yeast, with new ones being developed, is opening the way to the characterization of the core modular architecture and complex networks essential to all eukaryotes. Selected examples of the latest discoveries in eukaryote complexity and systems biology studies using yeast as a reference model and their applications in biotechnology and medicine are presented.

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Acknowledgments

This work was supported by BBSRC grants BB/C505140/2 and BB/F00446X/1 as well as by a contract from the European Commission under the FP7 Collaborative Programme, UNICELLSYS.

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  1. Department of Biochemistry, Cambridge Systems Biology Centre, University of Cambridge, Cambridge, CB2 1GA, UK

    Juan I. Castrillo & Stephen G. Oliver

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  1. Juan I. Castrillo
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Correspondence to Juan I. Castrillo .

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    Juan I. Castrillo

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    Stephen G. Oliver

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Castrillo, J.I., Oliver, S.G. (2011). Yeast Systems Biology: The Challenge of Eukaryotic Complexity. In: Castrillo, J., Oliver, S. (eds) Yeast Systems Biology. Methods in Molecular Biology, vol 759. Humana Press. https://doi.org/10.1007/978-1-61779-173-4_1

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