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Adjuvant Activity of Cytokines

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Vaccine Adjuvants

Part of the book series: Methods in Molecular Biology ((MIMB,volume 626))

Abstract

The activity of several potent adjuvants, including incomplete Freund’s adjuvant, CpG oligodeoxynucleotides, and alum, has been shown to be due at least in part to the induction of cytokines, including type I interferons (IFNs), IFN-γ, interleukin-2 (IL-2), and IL-12, that play key roles in the regulation of innate and adaptive immunity. The relatively short half-life of recombinant homologues of cytokines has limited their use as vaccine adjuvants. These difficulties have been overcome by encapsulation into liposomes and the use of cytokine expression vectors co-administered with DNA vaccines. Although a number of cytokines including IFN-α, IFN-γ, IL-2, IL-12, IL-15, IL-18, IL-21, GM-CSF, and Flt-3 ligand have been shown to potentiate the immune response to vaccination in various experimental models, the full potential of cytokines as vaccine adjuvants remains to be established.

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  1. Laboratory of Viral Oncology, FRE2937 CNRS, Institut André Lwoff, Villejuif, France

    Michael G. Tovey & Christophe Lallemand

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  1. Michael G. Tovey
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  2. Christophe Lallemand
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Correspondence to Michael G. Tovey .

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  1. Dept. Cardio & Vascular Sciences, St. George's University of London, Cranmer Terrace, London, SW17 0RE, United Kingdom

    Gwyn Davies

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Tovey, M.G., Lallemand, C. (2010). Adjuvant Activity of Cytokines. In: Davies, G. (eds) Vaccine Adjuvants. Methods in Molecular Biology, vol 626. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-585-9_19

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  • DOI: https://doi.org/10.1007/978-1-60761-585-9_19

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