Abstract
Ultra-sensitive detection based on surface plasmon resonance (SPR) was investigated using 3D nanogap arrays for colocalization of target molecular distribution and localized plasmon wave in the near-field. Colocalization was performed by oblique deposition of a dielectric mask layer to create nanogap at the side of circular and triangular nanoaperture, where fields localized by surface plasmon localization coincide with the spatial distribution of target molecular interactions. The feasibility of ultra-sensitivity was experimentally verified by measuring DNA hybridization. Triangular nanopattern provided an optimum to achieve highly amplified angular shifts and led to enhanced detection sensitivity on the order of 1 fg/mm2 in terms of molecular binding capacity. We confirmed improvement of SPR sensitivity by three orders of magnitude, compared with conventional SPR sensors, using 3D plasmonic nanogap arrays.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Kim D (2005) Effect of the azimuthal orientation on the performance of grating-coupled surface-plasmon resonance biosensors. Appl Optics 44:3218–3223
Campbell CT, Kim G (2007) SPR microscopy and its application to high-throughput analyses of biomolecular binding events and their kinetics. Biomaterials 28:2380–2392
Dasary SSR, Singh AK, Senapati D, Yu H, Ray PC (2009) Gold nanoparticle based label-free SERS probe for ultrasensitive and selective detection of trinitrotoluene. J Am Chem Soc 131:13806–13812
Vollmer F, Arnold S (2008) Whispering-gallery-mode biosensing: label-free detection down to single molecules. Nat Methods 5:591–596
Oh Y, Lee W, Kim Y, Kim D (2014) Self-aligned colocalization of 3D plasmonic nanogap arrays for ultra-sensitive surface plasmon resonance detection. Biosens Bioelectron 51:401–407
Byun KM, Kim S, Kim D (2005) Design study of highly sensitive nanowire-enhanced surface plasmon resonance biosensors using rigorous coupled wave analysis. Opt Express 13:3737–3742
Kim K, Yoon SJ, Kim D (2006) Nanowire-based enhancement of localized surface plasmon resonance for highly sensitive detection: a theoretical study. Opt Express 14:12419–12431
Moon S, Kim Y, Oh Y, Lee H, Kim HC, Lee K, Kim D (2012) Grating-based surface plasmon resonance detection of core-shell nanoparticle mediated DNA hybridization. Biosens Bioelectron 32:141–147
Yu H, Kim K, Ma K, Lee W, Choi JW, Yun CO, Kim D (2013) Enhanced detection of virus particles by nanoisland-based localized surface plasmon resonance. Biosens Bioelectron 41:249–255
Hoa XD, Kirk AG, Tabrizian M (2009) Enhanced SPR response from patterned immobilization of surface bioreceptors on nano-gratings. Biosens Bioelectron 24:3043–3048
Ma K, Kim DJ, Kim K, Moon S, Kim D (2010) Target-localized nanograting-based surface plasmon resonance detection toward label-free molecular biosensing. IEEE J Sel Topics Quantum Electron 16:1004–1014
Kim Y, Chung K, Lee W, Kim DH, Kim D (2012) Nanogap-based dielectric-specific colocalization for highly sensitive surface plasmon resonance detection of biotin-streptavidin interaction. Appl Phys Lett 101:233701
Yang H, Lee W, Hwang T, Kim D (2014) Probabilistic evaluation of surface-enhanced localized surface plasmon resonance biosensing. Opt Express 22:28412–28426
Ryu Y, Moon S, Oh Y, Kim Y, Lee T, Kim DH, Kim D (2014) Effect of coupled graphene oxide on the sensitivity of surface plasmon resonance detection. Appl Optics 53:1419–1426
Chung K, Rani A, Lee J-E, Kim JE, Kim Y, Yang H, Kim SO, Kim D, Kim DH (2015) A systematic study on the sensitivity enhancement in graphene plasmonics sensors based on layer-by-layer self-assembled graphene oxide multilayers and their reduced anologues. ACS Appl Mater Interfaces 7:144–151
Kubatkin S, Danilov A, Hjort M, Cornil J, Brédas J-L, Stuhr-Hansen N, Hedegård P, Bjørnholm T (2003) Single-electron transistor of a single organic molecule with access to several redox states. Nature 425:698–701
Elhadj S, Singh G, Saraf RF (2004) Optical properties of an immobilized DNA monolayer from 255 to 700 nm. Langmuir 20:5539–5543
Fromm DP, Sundaramurthy A, Schuck PJ, Kino G, Moerner WE (2004) Gap-dependent optical coupling of single “bowtie” nanoantennas resonant in the visible. Nano Lett 4:957–961
Haes AJ, Zou S, Schatz GC, Van Duyne RP (2004) Nanoscale optical biosensor: short range distance dependence of the localized surface plasmon resonance of noble metal nanoparticles. J Phys Chem B 108:6961–6968
Szunerits S, Castel X, Boukherroub R (2008) Surface plasmon resonance investigation of silver and gold rilms coated with thin indium tin oxide layers: Influence on stability and sensitivity. J Phys Chem C 112:15813–15817
Steel AB, Herne TM, Tarlov MJ (1998) Electrochemical quantitation of DNA immobilized on gold. Anal Chem 70:4670–4677
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer Science+Business Media LLC
About this protocol
Cite this protocol
Lee, W., Son, T., Lee, C., Oh, Y., Kim, D. (2017). Ultra-Sensitive Surface Plasmon Resonance Detection by Colocalized 3D Plasmonic Nanogap Arrays. In: Rasooly, A., Prickril, B. (eds) Biosensors and Biodetection. Methods in Molecular Biology, vol 1571. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6848-0_2
Download citation
DOI: https://doi.org/10.1007/978-1-4939-6848-0_2
Published:
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-6846-6
Online ISBN: 978-1-4939-6848-0
eBook Packages: Springer Protocols