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Cell Cycle Synchronization

Volume 1524 of the series Methods in Molecular Biology pp 331-349

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Molecular Network Dynamics of Cell Cycle Control: Periodicity of Start and Finish

  • Alida PalmisanoAffiliated withDepartment of Biological Sciences, Virginia TechDepartment of Computer Science, Virginia Tech Email author 
  • , Judit ZámborszkyAffiliated withHungarian Academy of Sciences, Research Centre for Natural Sciences, Institute of Enzymology
  • , Cihan OguzAffiliated withDepartment of Biological Sciences, Virginia Tech
  • , Attila Csikász-NagyAffiliated withRandall Division of Cell and Molecular Biophysics, Institute for Mathematical and Molecular Biomedicine, King’s College LondonFaculty of Information Technology and Bionics, Pázmány Péter Catholic University

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Abstract

The cell division cycle is controlled by a complex regulatory network which ensures that the phases of the cell cycle are executed in the right order. This regulatory network receives signals from the environment, monitors the state of the DNA, and decides timings of cell cycle events. The underlying transcriptional and post-translational regulatory interactions lead to complex dynamical responses, such as the oscillations in the levels of cell cycle proteins driven by intertwined biochemical reactions. A cell moves between different phases of its cycle similar to a dynamical system switching between its steady states. The complex molecular network driving these phases has been investigated in previous computational systems biology studies. Here, we review the critical physiological and molecular transitions that occur in the cell cycle and discuss the role of mathematical modeling in elucidating these transitions and understand cell cycle synchronization.

Key words

Systems biology Bistability Oscillation Mathematical and computational models Checkpoints Budding yeast Hysteresis Synchronization Periodic forcing