1. Preface

   • Yasutoshi Muto

   EditorialNotes Pages: i - i

2. Opening Remarks

   • Toshitsugu Oda

   OriginalPaper Pages: 1 - 1

3. The role of cytotoxic T lymphocytes and inflammatory cytokines in the pathogenesis of acute viral hepatitis

   • Francis V. Chisari

   Pathobiology of Viral Hepatitis Pages: 2 - 6

4. Mutations of hepatitis B virus liver disease

   • Toshiki Ehata
   • Wan-Long Chuang
   • Masao Omata

   Pathobiology of Viral Hepatitis Pages: 7 - 11

5. Cytotoxic T lymphocyte activity and HB virus mutant in chronic HB virus carriers

   • Shinichi Kakumu
   • Takaji Wakita
   • Yuji Ito

   Pathobiology of Viral Hepatitis Pages: 12 - 16

6. Discussion

   Pathobiology of Viral Hepatitis Pages: 17 - 19

7. Mechanisms and mediators in hepatic necrosis

   • Karl Decker

   Hepatic Necrosis Pages: 20 - 25

8. Patterns and pathobiology of hepatic necrosis in chronic viral hepatitis

   • Morikazu Onji
   • Norio Horiike
   • Yasuyuki Ohta

   Hepatic Necrosis Pages: 26 - 29

9. Network of cytokine and arachidonic acid cascade in acute hepatic failure

   • Yasuhiro Mizoguchi
   • Norifumi Kawada
   • Kenzo Kobayashi

   Hepatic Necrosis Pages: 30 - 32

10. Discussion

    Hepatic Necrosis Pages: 33 - 35

11. HGF and liver regeneration

    • George Michalopoulos

    Hepatic Regeneration Pages: 36 - 39

12. Natural killer cell may impair liver regeneration in fulminant hepatic failure

    • Hiroo Ohnishi
    • Yasutoshi Muto
    • Hisataka Moriwaki

    Hepatic Regeneration Pages: 40 - 44

13. Design of hepatocyte-specific extracellular matrices for hybrid artificial liver

    • Toshihiro Akaike
    • Seishiro Tobe
    • Kazukiyo Kobayashi

    Hepatic Regeneration Pages: 45 - 52

14. Discussion

    Hepatic Regeneration Pages: 53 - 56

15. Immunogenetics of autoimmune chronic active hepatitis

    • A. L. W. F. Eddleston

    Immunogenetics Pages: 57 - 62

16. Comparison of the clinical and immunogenetic features between patients with autoimmune hepatitis and patients with type C chronic active hepatitis

    • Kendo Kiyosawa
    • Takeshi Seki
    • Hidetoshi Inoko

    Immunogenetics Pages: 63 - 68

17. Immunogenetic background of hepatitis B virus infection and autoimmune hepatitis in Japan

    • Mikio Zeniya
    • Fumitoki Watanabe
    • Gotaro Toda

    Immunogenetics Pages: 69 - 75

18. Discussion

    Immunogenetics Pages: 76 - 80

19. The mechanism of action of transforming growth factor-β

    • Kohei Miyazono
    • Carl-Henrik Heldin

    Special Lecture (1): TGF-β Pages: 81 - 85

20. Discussion

    Special Lecture (1): TGF-β Pages: 86 - 87

21. The biology and biochemistry of interferon-gamma and its receptor

    • Robert D. Schreiber
    • Michael A. Farrar

    Special Lecture (2): IFN-γ Pages: 88 - 94

22. Discussion

    Special Lecture (2): IFN-γ Pages: 95 - 96

23. A role for cytokines as regulators of hepatic fibrogenesis

    • Francis R. Weiner
    • Silvia Degli Esposti
    • Mark A. Zern

    Hepatic Fibrosis Pages: 97 - 101

24. Role of hepatic sinusoidal cells in hepatic injury and fibrosis in the liver

    • Yasushi Shiratori
    • Tateo Kawase
    • Masao Omata

    Hepatic Fibrosis Pages: 102 - 106

25. Changes of the extracellular matrix and cells producing it in acute liver injury

    • Takato Ueno
    • Sadataka Inuzuka
    • Kyuichi Tanikawa

    Hepatic Fibrosis Pages: 107 - 111

26. Discussion

    Hepatic Fibrosis Pages: 112 - 115

27. Closing Remarks

    • Yasutoshi Muto

    Hepatic Fibrosis Pages: 116 - 117

28. Present status of fulminant hepatitis in Japan (1989–1991)

    • Yasutoshi Muto

    Selected up-to-date summaries of the research group of intractable hepatitis, the ministry of health and welfare of japan (1989–1991) Pages: 120 - 127

29. Report of the Research Subgroup of autoimmune hepatitis/primary biliary cirrhosis

    • Yasuyuki Ohta

    Selected up-to-date summaries of the research group of intractable hepatitis, the ministry of health and welfare of japan (1989–1991) Pages: 128 - 133

30. Present status of autoimmune hepatitis in Japan

    • Morikazu Onji
    • Takashi Nonaka
    • Yasuyuki Ohta

    Selected up-to-date summaries of the research group of intractable hepatitis, the ministry of health and welfare of japan (1989–1991) Pages: 134 - 138

31. Interferon therapy in hepatitis C—Refractory hepatitis

    • Shiro Uno

    Selected up-to-date summaries of the research group of intractable hepatitis, the ministry of health and welfare of japan (1989–1991) Pages: 139 - 142

32. First Digestive Disease Week of Japan and Thirty-Fifth Annual Autumn Meeting of the Japanese Society of Gastroenterology September 20–24, 1993, Kobe, Japan

    Notices Pages: 146 - 147