1. Contributors

   Announcement 01 June 1991 Pages: S5 - S6

2. Dedication

   Announcement 01 June 1991 Pages: S7 - S7

3. Foreword

   • T. H. Grasela Jr.
   • E. J. Antal

   EditorialNotes 01 June 1991 Pages: S9 - S10

4. An introduction to mixed effect modeling: Concepts, definitions, and justification

   • Lewis B. Sheiner
   • Thaddeus H. Grasela Jr.

   OriginalPaper 01 June 1991 Pages: S11 - S24

5. Pharmacostatistical modeling for observational data

   • Thaddeus H. Grasela Jr.
   • Lewis B. Sheiner

   OriginalPaper 01 June 1991 Pages: S25 - S36

6. The application of population pharmacokinetic analysis to large scale clinical efficacy trials

   • Edward J. Antal
   • Thaddeus H. Grasela Jr.
   • Randall B. Smith

   OriginalPaper 01 June 1991 Pages: S37 - S46

7. A population pharmacokinetic profile of imazodan in congestive heart failure patients

   • Stephen C. Olson

   OriginalPaper 01 June 1991 Pages: S47 - S58

8. The population pharmacokinetics of theophylline during the early postnatal period

   • Emory S. Martin III

   OriginalPaper 01 June 1991 Pages: S59 - S77

9. Population dose-response relationships determined from efficacy trials: The antihypertensive effect of atenolol and betaxolol

   • Nancy C. Sambol
   • William A. Clementi
   • Lewis B. Sheiner

   OriginalPaper 01 June 1991 Pages: S79 - S91

10. A multi-center study to evaluate the pharmacokinetic and clinical interactions between alprazolam and imipramine

    • Edward J. Antal
    • Thaddeus H. Grasela Jr.
    • Randall B. Smith

    OriginalPaper 01 June 1991 Pages: S93 - S100

11. Application of population analysis to physiological pharmacokinetics

    • Thomas M. Ludden
    • Sandra R. B. Allerheiligen
    • Raymond F. Burk

    OriginalPaper 01 June 1991 Pages: S101 - S113