Abstract
This paper extends a series of historical papers which demonstrated that the linear-no-threshold (LNT) model for cancer risk assessment was founded on ideological-based scientific deceptions by key radiation genetics leaders. Based on an assessment of recently uncovered personal correspondence, it is shown that some members of the United States (US) National Academy of Sciences (NAS) Biological Effects of Atomic Radiation I (BEAR I) Genetics Panel were motivated by self-interest to exaggerate risks to promote their science and personal/professional agenda. Such activities have profound implications for public policy and may have had a significant impact on the adoption of the LNT model for cancer risk assessment.
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Notes
Dobzhansky was invited to be a member of the BEAR I Genetics Panel, but could not participate due to a scheduling conflict. He subsequently became a member of the Genetics Panel for the BEAR II Committee in 1956.
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Acknowledgments
Long-term research activities in the area of dose–response have been supported by awards from the US Air Force and ExxonMobil Foundation over a number of years. Sponsors had no involvement in study design, collection, analysis, interpretation, writing, and decision to submit.
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Calabrese, E.J. The Genetics Panel of the NAS BEAR I Committee (1956): epistolary evidence suggests self-interest may have prompted an exaggeration of radiation risks that led to the adoption of the LNT cancer risk assessment model. Arch Toxicol 88, 1631–1634 (2014). https://doi.org/10.1007/s00204-014-1306-7
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DOI: https://doi.org/10.1007/s00204-014-1306-7