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Nanomaterial-based adsorbents: the prospect of developing new generation radionuclide generators to meet future research and clinical demands

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Abstract

Nanostructured materials by virtue of huge surface to volume ratios, altered physical properties, tailored surface chemistry, favorable adsorption characteristics, and enhanced surface reactivity resulting from the nanoscale dimensions, have attracted considerable attention as a new class of adsorbent material in column chromatographic separation. This emerging class of adsorbent represents an innovative paradigm and is expected to play an important role in the development of radionuclide generators for nuclear medicine. The optimal combination of suitable nanomaterial and appropriate parent/daughter radionuclide pair forms the basis of such generators. Development of such generators is currently under intensive investigations and the utility of such systems is expected to pave the way for broad panoply of diagnostic and therapeutic applications in nuclear medicine. While nanomaterial-based radionuclide generator is still in its infancy, the use of such novel class of adsorbents is expected to have potential impact on shaping the radionuclide generator technology of future generation. This review provides a comprehensive summary on the utility of nanomaterials as effective adsorbents in the development column chromatographic radionuclide generators for medical applications. This overview outlines a critical assessment of role of the nanosorbents, recent developments, the contemporary status, and key challenges and apertures to the near future.

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Acknowledgments

Research at the Bhabha Atomic Research Centre is part of the ongoing activities of the Department of Atomic Energy, India and is fully supported by government funding. The authors are grateful to Dr. Gursharan Singh, Associate Director, Radiochemistry and Isotope Group (I), Bhabha Atomic Research Centre for his valuable support to the isotope program.

Conflict of interest

The authors have declared no conflicting financial interest.

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  1. Isotope Applications and Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, 400 085, India

    Rubel Chakravarty & Ashutosh Dash

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Correspondence to Ashutosh Dash.

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Chakravarty, R., Dash, A. Nanomaterial-based adsorbents: the prospect of developing new generation radionuclide generators to meet future research and clinical demands. J Radioanal Nucl Chem 299, 741–757 (2014). https://doi.org/10.1007/s10967-013-2823-1

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