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An Apparatus for Production of Isotopically and Spin-Enriched Hydrogen for Induced Polarization Studies

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Abstract

An apparatus for the production of hydrogen for hydrogenation-induced polarization studies was developed. The apparatus provides hydrogen gas from a solid source, thereby simplifying the requirement for siting of the apparatus. The produced hydrogen can be either isotopically enriched (with deuterium) or spin-enriched (with parahydrogen). These specialty gases were produced at small predetermined quantities and ambient pressure. The properties of the hydrogen mixtures were characterized by gas-phase nuclear magnetic resonance. The T 1 of the hydrogen mixtures (3.7 ms) was not affected by para-enrichment. The line width of the hydrogen signal in the para-enriched mixture was 34% larger. The reaction of ethyl propiolate hydrogenation served to evaluate the performance in terms of the ability to create hyperpolarized states. In this reaction, a polarization of 11.2% was measured for protons. Consecutive alkene hydrogenations as well as hydrogenations of the catalyst ligand resulted in additional hyperpolarized signals which were systematically assigned.

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Acknowledgments

We thank Aaron K. Grant, Elena Vinogradova, and Robert E. Lenkinski for useful discussions during the course of this work. We thank Magnus Karlsson for helpful discussions on gas-phase NMR measurements. We thank Shimon Vega for discussions on orthodeuterium. This study has been supported in part by the DANA foundation, the Bi-National Science Foundation (BSF, grant number 2006118), the German Israel Foundation (GIF, grant number 2131-1586.5/2006), the Abisch-Frenkel Foundation, and the Center for Complexity Science (grant number GR2007-053). R.K.B thanks the generosity of the Tchorz fund, the Speijer inheritance fund, and the Goldin-Savad inheritance fund.

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Author notes

  1. Claudia M. Barzilay

    Present address: Bargal Analytical Instruments, Airport City, Israel

Authors and Affiliations

  1. Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

    Ayelet Gamliel, Hyla Allouche-Arnon, Ruppen Nalbandian, J. Moshe Gomori & Rachel Katz-Brull

  2. Department of Medicinal Chemistry, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel

    Claudia M. Barzilay

Authors
  1. Ayelet Gamliel
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  2. Hyla Allouche-Arnon
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  3. Ruppen Nalbandian
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  4. Claudia M. Barzilay
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  5. J. Moshe Gomori
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  6. Rachel Katz-Brull
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Correspondence to Rachel Katz-Brull.

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Gamliel, A., Allouche-Arnon, H., Nalbandian, R. et al. An Apparatus for Production of Isotopically and Spin-Enriched Hydrogen for Induced Polarization Studies. Appl Magn Reson 39, 329–345 (2010). https://doi.org/10.1007/s00723-010-0161-9

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  • DOI: https://doi.org/10.1007/s00723-010-0161-9

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