Analysis of the leaf metabolome in Arabidopsis thaliana mutation accumulation lines reveals association of metabolic disruption and fitness consequence
Authors (first, second and last of 8)
Collection
Topical Collection: Fitness Effects of Mutations
Mutation is often referred to as "the ultimate source of new variation" on which selection acts, yet mutation is not often the centerpiece of evolutionary considerations. With advances in genomics, molecular genetics and computational approaches, our ability to detect and evaluate the effects of mutation is occurring at a rapid rate. Such advances have demonstrated that mutation rates are variable by species, populations, areas of the chromosome and across different ecological environments. Data on distributions of mutational effects on phenotypes, particularly fitness phenotypes, are further enhanced by genomic, theoretical computational advances and taking these problems into ecological settings.
We have brought together ideas from theoretical, molecular, field, computational and various experimental approaches across organisms and systems and seek additional submissions for this growing topical collection of already well-cited articles.
Students and Early Career Researchers are especially encouraged to submit to this Topical Collection.
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Editors
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Charles B. Fenster
Prof. Fenster’s work is broadly conceptually driven, focused on the elucidation of evolutionary process using plants as model organisms. He uses a combination of approaches incorporating statistical, ecological, quantitative genetic and molecular marker based techniques to address the questions of his research program.
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Courtney J. Murren
Prof. Murren is interested in how phenotypes of organisms are built and interact with the environment. This leads to employment of ecological, developmental, genetic and statistical tools to ask questions about the evolution of phenotypic form. She has examined systems from orchids, to invasive species, to Brassica species, and Mimulus species. Prof. Murren's current research focuses on natural accessions and mutant lines of Arabidopsis thaliana.
Articles (13 in this collection)
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Thermal stress and mutation accumulation increase heat shock protein expression in Daphnia
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Intraspecific competitive interactions rapidly evolve via spontaneous mutations
Authors (first, second and last of 4)
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Are mutations usually deleterious? A perspective on the fitness effects of mutation accumulation
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Relaxed selection and the evolution of the chasmogamous flower of Impatiens capensis (Balsaminaceae)
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Correction to: CpG‑creating mutations are costly in many human viruses
Authors (first, second and last of 57)
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Disrupting the disruptors: the consequences of mutations in mobile elements for ecologically important life history traits
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The effect of environmental heterogeneity on the fitness of antibiotic resistance mutations in Escherichia coli
Authors (first, second and last of 4)
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