Chapter

Topics in Biomedical Gerontology

pp 67-89

Date:

Morphology of the Human Pancreas During Development and Aging

  • Renu GuptaAffiliated withDepartment of Anatomy, All India Institute of Medical Sciences
  • , Shubhi SainiAffiliated withDepartment of Anatomy, All India Institute of Medical Sciences
  • , Saroj SharmaAffiliated withDr. B.S. Ambedkar Medical College and Hospital
  • , Tony G. JacobAffiliated withDepartment of Anatomy, All India Institute of Medical Sciences
  • , T. S. RoyAffiliated withDepartment of Anatomy, All India Institute of Medical Sciences Email author 

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Abstract

Pancreas gets affected by fibrosis associated with aging. This study analyzed the age-related fibrotic changes in the ductular system of the pancreas. After obtaining necessary ethical clearances, twelve human fetal and thirty post-natal and adult pancreas were collected and processed to obtain resin-embedded sections for transmission electron microscopy and paraffin-embedded sections for H&E staining and light microscopy. The sections were analyzed qualitatively and quantitatively. The human pancreas had mature zymogen granules in the exocrine part and secretory granules in the endocrine part by 20th week of gestation. The amount of connective tissue and acini increased with age. After the 3rd decade, there was increased fibrosis. This began around small and medium sized ducts. Changes in the epithelium of ducts were seen in later decades. There was a direct correlation between area of the ducts and increasing age. There was increased fibrosis in and around the islets of Langerhans. The number of fibroblasts and stellate cells increased with age. The increased fibrosis with increasing age that first appears around the small and medium sized ducts may be due to increased number of pancreatic stellate cells.

Keywords

Stellate cells Zymogen granules Islets of langerhans Fibrosis Nucleator Transmission electron microscopy