Abstract
The aim of the present study was to evaluate the presence of Neuroglobin (Ngb) and Cytoglobin (Cygb) in the solitary tract nucleus (STN) and in the carotid body of human subjects. Transverse serial sections of formalin-fixed, paraffin-embedded brainstems, taken from six subjects, were investigated. Ngb and Cygb are expressed in both the structures. Differences in expression of Ngb and Cygb among dorsal and ventral area of the STN may be related to their different functions and different metabolic demands. Because the STN plays an important role in the processing of cardiovascular and respiratory reflex inputs, Ngb and Cygb may play an integrative central modulatory action for the two systems.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Allen, M. A., Smith, P. M., & Ferguson, A. V. (1997). Adrenomedullin microinjection into the area postrema increases blood pressure. American Journal of Physiology, 272, 1698–1703.
Andresen, M. C., & Kunze, D. L. (1994). Nucleus tractus solitarius gateway to neural circulatory control. Annual Review Physiology, 56, 93–116.
Bunn, H. F., & Poyton, R. O. (1996). Oxygen sensing and molecular adaptation to hypoxia. Physiological Reviews, 76, 839–885.
Burmester, T., & Hankeln, T. (2004). Neuroglobin: A respiratory protein of the nervous system. News in Physiological Sciences, 19, 110–113.
Burmester, B., Weich, S., Reinhardt, T., & Hankeln, T. (2000). A vertebrate globin expressed in the brain. Nature, 407, 520–523.
Dewilde, S., Kiger, L., Burmester, T., Hankeln, T., Baudin-Creuza, V., Aerts, T., Marden, M. C., Caubergs, R., & Moens, L. (2001). Biochemical characterization and ligand-binding properties of neuroglobin, a novel member of the globin family. Journal of Biological Chemistry, 276, 38949–38955.
Di Giulio, C., Bianchi, G., Cacchio, M., Macri, M. A.’., Ferrero, G., Rapino, C., Verratti, V., Piccirilli, M., & Artese, L. (2003). Carotid body HIF-1 alpha, VEGF, and NOS expression during aging and hypoxia. Advances in Experimental Medicine and Biology, 536, 603–610.
Gonzalez, C., Almaraz, L., Obeso, A., & Rigual, R. (1994). Carotid body chemoreceptors: From natural stimuli to sensory discharges. Physiology Reviews, 74, 829–898.
Lahiri, S., Di Giulio, C., & Roy, A. (2002). Lesson from chronic intermittent and sustained hypoxia. Respiratory Physiology & Neurobiology, 130, 223–233.
Mammen, P. P., Shelton, J. M., Goetsch, S. C., Williams, S. C., Richardson, J. A., Garry, M. G., & Garry, D. J. (2002). Neuroglobin: A novel member of the globin family is expressed in focal regions of brain. The Journal of Histochemistry and Cytochemistry, 50, 1591–1598.
Mifflin, S. W. (1992). Arterial chemoreceptor input to nucleus tractus solitarius. American Journal of Physiology, 263, 368–375.
Mifflin, S. W. (1993). Inhibition of chemoreceptor inputs to nucleus of tractus solitarius neurons during baroreceptor stimulation. American Journal of Physiology, 265, 14–20.
Paton, J. F. (1998). Convergence properties of solitary tract neurones driven synaptically by cardiac vagal afferents in the mouse. Journal of Physiology, 508, 237–252.
Pesce, A., Dewilde, S., Nardini, M., Moens, L., Ascenzi, P., Hankeln, T., Burmester, T., & Bolognesi, M. (2003). Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity. Structure, 3, 1146–1151.
Sander, G. E., Lowe, R. F., Given, M. B., & Giles, T. D. (1989). Interactions between circulating peptides and the central nervous system in hemodynamic regulation. The American Journal of Cardiology, 64, 44–50.
Silva-Carvalho, L., Paton, J. F., Rocha, I., Goldsmith, G. E., & Spyer, K. M. (1998). Convergence properties of solitary tract neurons responsive to cardiac receptor stimulation in the anesthetized cat. Journal of Neurophysiology, 79, 2374–2382.
Spyer, K. M., & Gourine, A. V. (2009). Chemosensory pathways in the brainstem controlling cardiorespiratory activity. Philosophical Transactions of the Royal Society Biological Sciences, 364, 2603–2610.
Sun, Y., Jin, K., Mao, X. O., Zhu, Y., & Greenberg, D. A. (2001). Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury. Proceedings of the National Academy of Sciences of the United States of America, 98, 15306–15311.
Szilagyi, J. E., & Ferrario, C. M. (1981). Central opiate system modulation of the area postrema pressor pathway. Hypertension, 3, 313–317.
Zhu, Y., Sun, Y., Jin, K., & Greenberg, D. A. (2002). Hemin induces neuroglobin expression in neural cells. Blood, 100, 2494–2498.
Conflicts of Interest
The authors declare no conflicts of interest in relation to this article.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Di Giulio, C. et al. (2013). Cytoglobin and Neuroglobin in the Human Brainstem and Carotid Body. In: Pokorski, M. (eds) Neurobiology of Respiration. Advances in Experimental Medicine and Biology, vol 788. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6627-3_9
Download citation
DOI: https://doi.org/10.1007/978-94-007-6627-3_9
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-6626-6
Online ISBN: 978-94-007-6627-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)