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Detection and Characterization of Intracranial Aneurysms with Dual-Energy Subtraction CTA: Comparison with DSA

  • Conference paper
Early Brain Injury or Cerebral Vasospasm

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 110/2))

Abstract

Background: To investigate the diagnostic performance of dual-energy subtraction CTA in evaluating intracranial aneurysms by comparison with DSA.

Methods: Ninety-seven patients with suspected intracranial aneurysms were included into our study and completed both 64-section dual-energy subtraction CTA and DSA examinations. Two independent readers retrospectively reviewed all subtraction CTA images in a blinded manner. Sensitivity, specificity, positive predictive value and negative predictive value of subtraction CTA and DSA were calculated on a per-patient and per-aneurysm basis.

Results: According to the reference standard, 96 aneurysms were present in 81 patients and no aneurysm was found in 16 patients. The overall sensitivity, specificity, positive predictive value and negative predictive value of subtraction CTA on a per-aneurysm basis were 98.9, 100, 100 and 94.1%, respectively. DSA prospectively detected 88 aneurysms in 79 of 81 patients. On a per-aneurysm basis, the sensitivity, specificity, positive predictive value and negative predictive value of DSA were 91.7, 100, 100 and 66.7%, respectively.

Conclusion: The diagnostic accuracy of 64-section dual-energy subtraction CTA is promising in detection and characterization of intracranial aneurysms. In most cases, it may substitute for conventional DSA as the primary imaging method in the diagnostic work-up of intracranial aneurysms.

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Acknowledgement

This work was supported by a grant from National Basic Research Program of China (973 Program No. 2009CB918300).

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Authors and Affiliations

  1. Department of Radiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China

    Fajin Lv & Tianyou Luo

  2. Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong District, 400016, Chongqing, China

    Qi Li, John Zhang & Peng Xie MD

  3. Institute of Neuroscience, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong District, 400016, Chongqing, China

    Qi Li, John Zhang & Peng Xie MD

  4. GE China CT Imaging Research Center, Beijing, China

    Jingmin Liao & Yun Shen

  5. Department of Medicine, Chongqing Medical and Pharmaceutical College, Chongqing, China

    Jialun Li

  6. Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, USA

    John Zhang

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  1. Fajin Lv
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Correspondence to Peng Xie MD .

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Editors and Affiliations

  1. Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Gaotanyan 30, Chongqing, 400038, China

    Hua Feng

  2. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China

    Ying Mao

  3. Departments of Physiology and Neurosurgery, Loma Linda University School of Medicine, Risley Hall, Room 223, 92354, Loma Linda, California, USA

    John H. Zhang

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Lv, F. et al. (2011). Detection and Characterization of Intracranial Aneurysms with Dual-Energy Subtraction CTA: Comparison with DSA. In: Feng, H., Mao, Y., Zhang, J.H. (eds) Early Brain Injury or Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 110/2. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0356-2_43

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  • DOI: https://doi.org/10.1007/978-3-7091-0356-2_43

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-0355-5

  • Online ISBN: 978-3-7091-0356-2

  • eBook Packages: MedicineMedicine (R0)

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