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Biokinetic Models for Radiopharmaceuticals

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Radiation Physics for Nuclear Medicine

Abstract

Radiopharmaceuticals administered for diagnostic or therapeutic applications in humans are selectively transported into specific organs and tissues of the body, metabolised, and finally excreted according to their biochemical and metabolic properties. Due to the presence of the radioactive label, each of the body regions containing the substance becomes an emitting source (source region), which can also irradiate the neighbouring tissues (defined as target regions). Consequently, each body organ or tissue could receive a radiation dose (absorbed dose) after administration of radiopharmaceuticals even if no activity is present in it. The absorbed dose delivered by incorporated radioactive material is called the internal dose. Direct measurements of the internal dose are not possible for evident practical reasons, so this quantity has to be calculated using a mathematical approach. Such an approach has to take into account that

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Author information

Authors and Affiliations

  1. Department of Medical Radiation Physics and Diagnostics, Helmholtz Zentrum München, 85764, Neuherberg, Germany

    Augusto Giussani

  2. Medical Radiation Physics, Lund University, Malmö, Sweden

    Helena Uusijärvi

Authors
  1. Augusto Giussani
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  2. Helena Uusijärvi
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Corresponding author

Correspondence to Augusto Giussani .

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Editors and Affiliations

  1. , Dept. of Physics, Università degli Studi di Milano, Via Celoria 16, Milano, 20133, Italy

    Marie Claire Cantone

  2. Gesundheit und Umwelt (GmbH), Helmholtz Zentrum München, Deutsches Forschungszentrum für, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany

    Christoph Hoeschen

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Giussani, A., Uusijärvi, H. (2011). Biokinetic Models for Radiopharmaceuticals. In: Cantone, M., Hoeschen, C. (eds) Radiation Physics for Nuclear Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11327-7_13

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  • DOI: https://doi.org/10.1007/978-3-642-11327-7_13

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-11326-0

  • Online ISBN: 978-3-642-11327-7

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