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CD1 Expression on Antigen-Presenting Cells

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T Cell Activation by CD1 and Lipid Antigens

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 314))

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References

  • Adly MA, Assaf HA, Hussein M (2005) Expression of CD1d in human scalp skin and hair follicles: hair cycle related alterations. J Clin Pathol 58:1278–1282

    PubMed  CAS  Google Scholar 

  • Amano M et al (1998) CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta 2-microglobulin-dependent and independent forms. J Immunol 161:1710–1717

    PubMed  CAS  Google Scholar 

  • Amanuma R, Nakajima T, Yoshie H, Yamazaki K (2006) Increased infiltration of CD1d and natural killer T cells in periodontal disease tissues. J Periodontal Res 41:73–79

    PubMed  CAS  Google Scholar 

  • Angel CE, George E, Brooks AE, Ostrovsky LL, Brown TL, Dunbar PR (2006) Cutting edge: CD1a+ antigen-presenting cells in human dermis respond rapidly to CCR7 ligands. J Immunol 176:5730–5734

    PubMed  CAS  Google Scholar 

  • Angenieux C, Salamero J, Fricker D, Cazenave JP, Goud B, Hanau D, de La Salle H (2000) Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells. J Biol Chem 275:37757–37764

    PubMed  CAS  Google Scholar 

  • Angenieux C, Fraisier V, Maitre B, Racine V, van der Wel N, Fricker D, Proamer F, Sachse M, Cazenave JP, Peters P, Goud B, Hanau D, Sibarita JB, Salamero J, de la Salle H (2005) The cellular pathway of CD1e in immature and maturing dendritic cells. Traffic 6:286–302

    PubMed  CAS  Google Scholar 

  • Balk SP, Bleicher PA, Terhorst C (1989) Isolation and characterization of a cDNA and gene coding for a fourth CD1 molecule. Proc Natl Acad Sci U S A 86:252–256

    PubMed  CAS  Google Scholar 

  • Balk SP et al (1994) Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium. Science 265:259–262

    PubMed  CAS  Google Scholar 

  • Banchereau J et al (2000) Immunobiology of dendritic cells. Annu Rev Immunol 18:767–811

    PubMed  CAS  Google Scholar 

  • Battistini L, Fischer FR, Raine CS, Brosnan CF (1996) CD1b is expressed in multiple sclerosis lesions. J Neuroimmunol 67:145–151

    PubMed  CAS  Google Scholar 

  • Bell D et al (1999) In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritumoral areas. J Exp Med 190:1417–1426

    PubMed  CAS  Google Scholar 

  • Bendelac A, Killeen N, Littman DR, Schwartz RH (1994) A subset of CD4+ thymocytes selected by MHC class I molecules. Science 263:1774–1778

    PubMed  CAS  Google Scholar 

  • Bendelac A, Hunziker RD, Lantz O (1996) Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells. J Exp Med 184:1285–1293

    PubMed  CAS  Google Scholar 

  • Bezbradica JS, Stanic AK, Matsuki N et al (2005) Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. J Immunol 174:4696–4705

    PubMed  CAS  Google Scholar 

  • Bleicher PA, Balk SP, Hagen SJ, Blumberg RS, Flotte TJ, Terhorst C (1990) Expression of murine CD1 on gastrointestinal epithelium. Science 250:679–682

    PubMed  CAS  Google Scholar 

  • Blumberg RS, Turnhorst C, Bleicher P et al (1991) Expression of a nonpolymorphic MHC class I-like molecule CD1D, by human intestinal epithelial cells. J Immunol 147:2518–2524

    PubMed  CAS  Google Scholar 

  • Bonish B, Jullien D, Dutronc Y et al (2000) Overexpression of CD1d by keratinocytes in psoriasis and CD1d-dependent IFN-gamma production by NK-T cells. J Immunol 165:4076–4085

    PubMed  CAS  Google Scholar 

  • Bradbury A, Belt KT, Neri TM, Milstein C, Calabi F (1988) Mouse CD1 is distinct from and co-exists with TL in the same thymus. EMBO J 7:3081–3086

    PubMed  CAS  Google Scholar 

  • Bradbury A, Calabi F, Milstein C (1990) Expression of CD1 in the mouse thymus. Eur J Immunol 20:1831–1836

    PubMed  CAS  Google Scholar 

  • Brossay L, Jullien D, Cardell S et al (1997) Mouse CD1 is mainly expressed on hemopoietic-derived cells. J Immunol 159:1216–1224

    PubMed  CAS  Google Scholar 

  • Brossay L, Tangri S, Bix M, Cardell S, Locksley R, Kronenberg M (1998) Mouse CD1-autoreactive T cells have diverse patterns of reactivity to CD1+ targets. J Immunol 160:3681–3688

    PubMed  CAS  Google Scholar 

  • Brozovic S, Nagaishi T, Yoshida M, Betz S, Salas A, Chen D, Kaser A, Glickman J, Kuo T, Little A, Morrison J, Corazza N, Kim JY, Colgan SP, Young SG, Exley M, Blumberg RS (2004) CD1d function is regulated by microsomal triglyceride transfer protein. Nat Med 10:535–539

    PubMed  CAS  Google Scholar 

  • Brutkiewicz RR, Bennink JR, Yewdell JW, Bendelac A (1995) TAP-independent, beta 2-microglobulin-dependent surface expression of functional mouse CD1.1. J Exp Med 182:1913–1919

    PubMed  CAS  Google Scholar 

  • Burke S, Landau S, Green R et al (1994) Rat cluster of differentiation 1 molecule: expression on the surface of intestinal epithelial cells and hepatocytes. Gastroenterology 106:1143–1149

    PubMed  CAS  Google Scholar 

  • Busshoff U, Hein A, Iglesias A, Dorries R, Regnier-Vigouroux A (2001) CD1 expression is differentially regulated by microglia, macrophages and T cells in the central nervous system upon inflammation and demyelination. J Neuroimmunol 113:220–230

    PubMed  CAS  Google Scholar 

  • Campbell NA, Kim HS, Blumberg RS, Mayer L (1999) The nonclassical class I molecule CD1d associates with the novel CD8 ligand gp180 on intestinal epithelial cells. J Biol Chem 274:26259–26265

    PubMed  CAS  Google Scholar 

  • Campos-Martin Y, Colmenares M, Gozalbo-Lopez B, Lopez-Nunez M, Savage PB, Martinez-Naves E (2006) Immature human dendritic cells infected with Leishmania infantum are resistant to NK-mediated cytolysis but are efficiently recognized by NKT cells. J Immunol 176:6172–6179

    PubMed  CAS  Google Scholar 

  • Canchis PW, Bhan AK, Landau SB, Yang L, Balk SP, Blumberg RS (1993) Tissue distribution of the non-polymorphic major histocompatibility complex class I-like molecule CD1d. Immunology 80:561–565

    PubMed  CAS  Google Scholar 

  • Cao X, Sugita M, Van der Wel N et al (2002) CD1 molecules efficiently present antigen in immature dendritic cells and traffic independently of MHC class II during dendritic cell maturation. J Immunol 169:4770–4777

    PubMed  Google Scholar 

  • Cardell S, Tangri S, Chan S, Kronenberg M, Benoist C, Mathis D (1995) CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice. J Exp Med 182:993–1004

    PubMed  CAS  Google Scholar 

  • Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J (1992) GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature 360:258–261

    PubMed  CAS  Google Scholar 

  • Caux C, Vanbervliet B, Massacrier C et al (1996) CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha. J Exp Med 184:695–706

    PubMed  CAS  Google Scholar 

  • Chen N et al (2006) HIV-1 down-regulates the expression of CD1d via Nef. Eur J Immunol 36:278–286

    PubMed  CAS  Google Scholar 

  • Chen QY, Jackson N (2004) Human CD1D gene has TATA boxless dual promoters: an SP1-binding element determines the function of the proximal promoter. J Immunol 172:5512–5521

    PubMed  CAS  Google Scholar 

  • Chen YH, Wang B, Chun T et al (1999) Expression of CD1d2 on thymocytes is not sufficient for the development of NKT cells in CD1d1-deficient mice. J Immunol 162:4560–4566

    PubMed  CAS  Google Scholar 

  • Chun T, Page MJ, Gapin L et al (2003) CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells. J Exp Med 197:907–918

    PubMed  CAS  Google Scholar 

  • Cipriani B, Chen L, Hiromatsu K et al (2003) Upregulation of group 1. CD1 antigen presenting molecules in guinea pigs with experimental autoimmune encephalomyelitis: an immunohistochemical study. Brain Pathol 13:1–9

    PubMed  Google Scholar 

  • Colgan SP, Morales VM, Madara JL, Polischuk JE, Balk SP, Blumberg RS (1996) IFN-gamma modulates CD1d surface expression on intestinal epithelia. Am J Physiol 271:C276–C283

    PubMed  CAS  Google Scholar 

  • Colgan SP, Hershberg RM, Furuta GT, Blumberg RS (1999) Ligation of intestinal epithelial CD1d induces bioactive IL-10: critical role of the cytoplasmic tail in autocrine signaling. Proc Natl Acad Sci U S A 96:13938–13943

    PubMed  CAS  Google Scholar 

  • Colgan SP et al (2003) Intestinal heat shock protein 110 regulates expression of CD1d on intestinal epithelial cells. J Clin Invest 112:745–754

    PubMed  CAS  Google Scholar 

  • De la Salle H Mariotti S, Angenieux C, Gilleron M, Garcia-Alles LF, Malm D et al (2005) Assistance of microbial glycolipid antigen processing by CD1e. Science 310:1321–1324

    PubMed  Google Scholar 

  • Delia D, Cattoretti G, Polli N et al (1988) CD1c but neither CD1a nor CD1b molecules are expressed on normal, activated, and malignant human B cells: identification of a new B-cell subset. Blood 72:241–247

    PubMed  CAS  Google Scholar 

  • Dhodapkar KM, Cirignano B, Chamian F et al (2004) Invariant natural killer T cells are preserved in patients with glioma and exhibit antitumor lytic activity following dendritic cell-mediated expansion. Int J Cancer 109:893–899

    PubMed  CAS  Google Scholar 

  • Dhodapkar MV, Geller MD, Chang DH et al (2003) A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myeloma. J Exp Med 197:1667–1676

    PubMed  CAS  Google Scholar 

  • Dougan SKSA, Rava P, Agyemang A, Kaser A, Morrison J, Khurana A, Kronenberg M, Johnson C, Exley M, Hussain MM, Blumberg RS (2005) Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. J Exp Med 202:529–539

    PubMed  CAS  Google Scholar 

  • Duperrier K, Eljaafari H, Dezutter-Dambuyant C et al (2000) Distinct subsets of dendritic cells resembling dermal DCs can be generated in vitro from monocytes, in the presence of different serum supplements. J Immunol Methods 238:119–131

    PubMed  CAS  Google Scholar 

  • Durante-Mangoni E et al (2004) Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells. J Immunol 173:2159–2166

    PubMed  CAS  Google Scholar 

  • Exley M, Garcia J, Wilson SB et al (2000) CD1d structure and regulation on human thymocytes, peripheral blood T cells B cells and monocytes. Immunology 100:37–47

    PubMed  CAS  Google Scholar 

  • Fainboim L, Salamone Mdel C (2002) CD1: a family of glycolypid-presenting molecules or also immunoregulatory proteins? J Biol Regul Homeost Agents 16:125–135

    PubMed  CAS  Google Scholar 

  • Fais F, Morabito F, Stelitano C et al (2004) CD1d is expressed on B-chronic lymphocytic leukemia cells and mediates alpha-galactosylceramide presentation to natural killer T lymphocytes. Int J Cancer 109:402–411

    PubMed  CAS  Google Scholar 

  • Feng CG, Demangel C, Kamath AT, Macdonald M, Britton WJ (2001) Dendritic cells infected with Mycobacterium bovis bacillus Calmette Guerin activate CD8(+) T cells with specificity for a novel mycobacterial epitope. Int Immunol 13:451–458

    PubMed  CAS  Google Scholar 

  • Fiedler T, Walter W, Reichert TE, Maeurer MJ (2002) Regulation of CD1d expression by murine tumor cells: escape from immunosurveillance or alternate target molecules? Int J Cancer 98:389–397

    PubMed  CAS  Google Scholar 

  • Fishelevich R, Malalina A, Luzina I et al (2006) Ceramide-dependent regulation of human epidermal keratinocyte CD1d expression during terminal differentiation. J Immunol 176:2590–2599

    PubMed  CAS  Google Scholar 

  • Fivenson DP, Nickoloff BJ (1995) Distinctive dendritic cell subsets expressing factor XIIIa CD1a CD1b and CD1c in mycosis fungoides and psoriasis. J Cutan Pathol 22:223–228

    PubMed  CAS  Google Scholar 

  • Fuss IJ, Heller F, Boirivant M et al (2004) Nonclassical CD1d-restricted NKT cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest 113:1490–1497

    PubMed  CAS  Google Scholar 

  • Galli G, Nuti S, Tavarini S et al (2003) CD1d-restricted help to B cells by human invariant natural killer T lymphocytes. J Exp Med 197:1051–1057

    PubMed  CAS  Google Scholar 

  • Geng Y, Laslo P, Barton K, Wang CR (2005) Transcriptional regulation of CD1D1 by Ets family transcription factors. J Immunol 175:1022–1029

    PubMed  CAS  Google Scholar 

  • Gerlini G, Hefti HP, Kleinhans M, Nickoloff BJ, Burg G, Nestle FO (2001) Cd1d is expressed on dermal dendritic cells and monocyte-derived dendritic cells. J Invest Dermatol 117:576–582

    PubMed  CAS  Google Scholar 

  • Gillessen S, Naumov YN, Niuwenhuis EE et al (2003) CD1d-restricted T cells regulate dendritic cell function and antitumor immunity in a granulocyte-macrophage colony-stimulating factor-dependent fashion. Proc Natl Acad Sci U S A 100:8874–8879

    PubMed  CAS  Google Scholar 

  • Goepel JR, Rees RC, Rogers K, Stoddard CJ, Thomas WE, Shepherd L (1991) Loss of monomorphic and polymorphic HLA antigens in metastatic breast and colon carcinoma. Br J Cancer 64:880–883

    PubMed  CAS  Google Scholar 

  • Hameg A, Apostolu I, Leite-De-Moraes M et al (2000) A subset of NKT cells that lacks the NK1.1 marker, expresses CD1d molecules, and autopresents the alpha-galactosylceramide antigen. J Immunol 165:4917–4926

    PubMed  CAS  Google Scholar 

  • Hansen DS, Siomos MA, De Koning-Ward T, Buckingham L, Crabb BS, Schofield L (2003) CD1d-restricted NKT cells contribute to malarial splenomegaly and enhance parasite-specific antibody responses. Eur J Immunol 33:2588–2598

    PubMed  CAS  Google Scholar 

  • Heller F, Fuss IJ, Nieuwenhuis EE, Blumberg RS, Strober W (2002) Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity 17:629–638

    PubMed  CAS  Google Scholar 

  • Hornung M, Farkas SA, Sattler C, Schlitt HJ, Geissler EK (2006) DX5(+)NKT cells induce the death of colitis-associated cells: involvement of programmed death ligand-1. Eur J Immunol 36:1210–1221

    PubMed  CAS  Google Scholar 

  • Ichimiya S, Kikuchi K, Matsuura A (1994) Structural analysis of the rat homologue of CD1. Evidence for evolutionary conservation of the CD1D class and widespread transcription by rat cells. J Immunol 153:1112–1123

    PubMed  CAS  Google Scholar 

  • Iwamoto M et al (2003) Prognostic value of tumor-infiltrating dendritic cells expressing CD83 in human breast carcinomas. Int J Cancer 104:92–97

    PubMed  CAS  Google Scholar 

  • Jenkinson HJ, Wainwright SD, Simpson KL, Perry AC, Fotiadou P, Holmes CH (1999) Expression of CD1D mRNA transcripts in human choriocarcinoma cell lines and placentally derived trophoblast cells. Immunology 96:649–655

    PubMed  CAS  Google Scholar 

  • Kang SJ, Cresswell P (2002) Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain. J Biol Chem 277:44838–44844

    PubMed  CAS  Google Scholar 

  • Kasai K, Matsuura A, Kikuchi K, Hashimoto Y, Ichimiya S (1997) Localization of rat CD1 transcripts and protein in rat tissues-an analysis of rat CD1 expression by in situ hybridization and immunohistochemistry. Clin Exp Immunol 109:317–322

    PubMed  CAS  Google Scholar 

  • Kim HS, Colgan SP, Pitman R, Hershberg RM, Blumberg RS (2000) Human CD1d associates with prolyl-4-hydroxylase during its biosynthesis. Mol Immunol 37:861–868

    PubMed  CAS  Google Scholar 

  • Kitamura H, Iwakabe A, Yahata T et al (1999) The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J Exp Med 189:1121–1128

    PubMed  CAS  Google Scholar 

  • Knowles RW, Bodmer WF (1982) A monoclonal antibody recognizing a human thymus leukemia-like antigen associated with beta 2-microglobulin. Eur J Immunol 12:676–681

    PubMed  CAS  Google Scholar 

  • Kojo S, Adachi Y, Tsutsumi A, Sumida T (2000) Alternative splicing forms of the human CD1D gene in mononuclear cells. Biochem Biophys Res Commun 276:107–111

    PubMed  CAS  Google Scholar 

  • Lacasse J, Martin LH (1992) Detection of CD1 mRNA in Paneth cells of the mouse intestine by in situ hybridization. J Histochem Cytochem 40:1527–1534

    PubMed  CAS  Google Scholar 

  • Lerch PG, van de Rijn M, Smart JE, Knowles RW, Terhorst C (1986) Isolation and purification of the human thymocyte antigens T6 and M241. Mol Immunol 23:131–139

    PubMed  CAS  Google Scholar 

  • Lin Y, Roberts TJ, Spence PM, Brutkiewicz RR (2005) Reduction in CD1d expression on dendritic cells and macrophages by an acute virus infection. J Leukoc Biol 77:151–158

    PubMed  CAS  Google Scholar 

  • Mach N, Gillessen S, Wilson SB, Sheehan C, Mihm M, Dranoff G (2000) Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand. Cancer Res 60:3239–3246

    PubMed  CAS  Google Scholar 

  • Makowska A, Faizunnessa NN, Anderson P, Midtvedt T, Cardell S (1999) CD1high B cells: a population of mixed origin. Eur J Immunol 29:3285–3294

    PubMed  CAS  Google Scholar 

  • Mandal M, Chen XR, Alegre ML et al (1998) Tissue distribution, regulation and intracellular localization of murine CD1 molecules. Mol Immunol 35:525–536

    PubMed  CAS  Google Scholar 

  • Manolova V, Kistoska M, Paoletti S et al (2006) Functional CD1a is stabilized by exogenous lipids. Eur J Immunol 36:1083–1092

    PubMed  CAS  Google Scholar 

  • Marschner A, Rothenfusser S, Hornung V et al (2005) CpGODN enhance antigen-specific NKT cell activation via plasmacytoid dendritic cells. Eur J Immunol 35:2347–2357

    PubMed  CAS  Google Scholar 

  • Martino A, Volpe E, Auricchio G, Colizzi V, Baldini PM (2006) Influence of Pertussis toxin on CD1a isoform expression in human dendritic cells. J Clin Immunol 26:153–159

    PubMed  CAS  Google Scholar 

  • McMichael AJ (1987) Leucocyte typing III: white cell differentiation antigens. Oxford University Press Oxford, New York

    Google Scholar 

  • McMichael AJ, Pilch JR, Galfre G, Mason DY, Fabre JW, Milstein C (1979) A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody. Eur J Immunol 9:205–210

    PubMed  CAS  Google Scholar 

  • Melian A, Geng YJ, Sukhova GK, Libby P, Porcelli SA (1999) CD1 expression in human atherosclerosis. A potential mechanism for T cell activation by foam cells. Am J Pathol 155:775–786

    PubMed  CAS  Google Scholar 

  • Metelitsa LS, Weinberg KI, Emanuel PD, Seeger RC (2003) Expression of CD1d by myelomonocytic leukemias provides a target for cytotoxic NKT cells. Leukemia 17:1068–1077

    PubMed  CAS  Google Scholar 

  • Mizoguchi A, Mizoguchi E, Takedatsu H, Blumberg RS, Bhan AK (2002) Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity 16:219–230

    PubMed  CAS  Google Scholar 

  • Mizoguchi A, Bhan AK (2006) A case for regulatory B cells. J Immunol 176:705–710

    PubMed  CAS  Google Scholar 

  • Morita M, Motoki K, Akimoto K et al (1995) Structure-activity relationship of alpha-galactosylceramides against B16-bearing mice. J Med Chem 38:2176–2187

    PubMed  CAS  Google Scholar 

  • Mosser DD, Duchaine J, Martin LH (1991) Biochemical and developmental characterization of the murine cluster of differentiation 1 antigen. Immunology 73:298–303

    PubMed  CAS  Google Scholar 

  • Nebozhyn M, Loboda A, Kari L et al (2006) Quantitative PCR on 5 genes reliably identifies CTCL patients with 5% to 99% circulating tumor cells with 90% accuracy. Blood 107:3189–3196

    PubMed  CAS  Google Scholar 

  • Nickoloff BJ, Wrone-Smith T, Bonish B, Porcelli SA (1999) Response of murine and normal human skin to injection of allogeneic blood-derived psoriatic immunocytes: detection of T cells expressing receptors typically present on natural killer cells, including CD94, CD158, and CD161. Arch Dermatol 135:546–552

    PubMed  CAS  Google Scholar 

  • Nickoloff BJ, Bonish B, Huang BB, Porcelli SA (2000) Characterization of a T cell line bearing natural killer receptors and capable of creating psoriasis in a SCID mouse model system. J Dermatol Sci 24:212–225

    PubMed  CAS  Google Scholar 

  • Nicol A et al (2000) Dendritic cells are targets for human invariant Valpha24+ natural killer T-cell cytotoxic activity: an important immune regulatory function. Exp Hematol 28:276–282

    PubMed  CAS  Google Scholar 

  • Nieda M, Nicol A, Koezuka Y et al (2001) TRAIL expression by activated human CD4(+)V alpha 24NKT cells induces in vitro and in vivo apoptosis of human acute myeloid leukemia cells. Blood 97:2067–2074

    PubMed  CAS  Google Scholar 

  • Nieuwenhuis EE, Matsumoto T, Exley M et al (2002) CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat Med 8:588–593

    PubMed  CAS  Google Scholar 

  • Nishimura T, Kitamura H, Iwakabe A et al (2000) The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes. Int Immunol 12:987–994

    PubMed  CAS  Google Scholar 

  • Olive D, Dubreuil P, Mawas C (1984) Two distinct TL-like molecular subsets defined by monoclonal antibodies on the surface of human thymocytes with different expression on leukemia lines. Immunogenetics 20:253–264

    PubMed  CAS  Google Scholar 

  • Osman Y, Kawamura T, Naito T et al (2000) Activation of hepatic NKT cells and subsequent liver injury following administration of alpha-galactosylceramide. Eur J Immunol 30:1919–1928

    PubMed  CAS  Google Scholar 

  • Page G, Lebecque S, Miossec P (2002) Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium. J Immunol 168:5333–5341

    PubMed  CAS  Google Scholar 

  • Page MJ, Poritz LS, Tilberg AF, Zhang WJ, Chorney MJ, Koltun WA (2000) Cd1d-restricted cellular lysis by peripheral blood lymphocytes: relevance to the inflammatory bowel diseases. J Surg Res 92:214–221

    PubMed  CAS  Google Scholar 

  • Park SH, Roark JH, Bendelac A (1998) Tissue-specific recognition of mouse CD1 molecules. J Immunol 160:3128–3134

    PubMed  CAS  Google Scholar 

  • Pena-Cruz V, Ito S, Dascher CC, Brenner MB, Sugita M (2003) Epidermal Langerhans cells efficiently mediate CD1a-dependent presentation of microbial lipid antigens to T cells. J Invest Dermatol 121:517–521

    PubMed  CAS  Google Scholar 

  • Pietschmann P, Stockl J, Draxler S, Majdic O, Knapp W (2000) Functional and phenotypic characteristics of dendritic cells generated in human plasma supplemented medium. Scand J Immunol 51:377–383

    PubMed  CAS  Google Scholar 

  • Pillai S, Cariappa A, Moran ST (2005) Marginal zone B cells. Annu Rev Immunol 23:161–196

    PubMed  CAS  Google Scholar 

  • Plebani A, Proserpio AR, Guarneri D, Buscaglia M, Cattoretti G (1993) B and T lymphocyte subsets in fetal and cord blood: age-related modulation of CD1c expression. Biol Neonate 63:1–7

    PubMed  CAS  Google Scholar 

  • Renukaradhya GJ et al (2005) Virus-induced inhibition of CD1d1-mediated antigen presentation: reciprocal regulation by p38 and ERK. J Immunol 175:4301–4308

    PubMed  CAS  Google Scholar 

  • Roark JH, Park SH, Jayawardena J, Kavita U, Shannon M, Bendelac A (1998) CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells. J Immunol 160:3121–3127

    PubMed  CAS  Google Scholar 

  • Romero JF, Eberl G, MacDonald HR, Corradin G (2001) CD1d-restricted NKT cells are dispensable for specific antibody responses and protective immunity against liver stage malaria infection in mice. Parasite Immunol 23:267–269

    PubMed  CAS  Google Scholar 

  • Ronger-Savle S et al (2005) TGFbeta inhibits CD1d expression on dendritic cells. J Invest Dermatol 124:116–118

    PubMed  CAS  Google Scholar 

  • Roura-Mir C, Catalfamo M, Cheng TY et al (2005a) CD1a and CD1c activate intrathyroidal T cells during Graves’ disease and Hashimoto’s thyroiditis. J Immunol 174:3773–3780

    PubMed  CAS  Google Scholar 

  • Roura-Mir C, Wang L, Cheng TY et al (2005b) Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2. J Immunol 175:1758–1766

    PubMed  CAS  Google Scholar 

  • Ryll R, Watanabe K, Fujiwara N et al (2001) Mycobacterial cord factor, but not sulfolipid, causes depletion of NKT cells and upregulation of CD1d1 on murine macrophages. Microbes Infect 3:611–619

    PubMed  CAS  Google Scholar 

  • Salamone MC, Rabinovich GA, Mendiguren AK, Salamone GV, Fainboim L (2001) Activation-induced expression of CD1d antigen on mature T cells. J Leukoc Biol 69:207–214

    PubMed  CAS  Google Scholar 

  • Sallinen K, Verajankorva E, Pollanen P (2000) Expression of antigens involved in the presentation of lipid antigens and induction of clonal anergy in the female reproductive tract. J Reprod Immunol 46:91–101

    PubMed  CAS  Google Scholar 

  • Sanchez DJ, Gumperz JE, Ganem D (2005) Regulation of CD1d expression and function by a herpesvirus infection. J Clin Invest 115:1369–1378

    PubMed  CAS  Google Scholar 

  • Saubermann LJ et al (2000) Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice. Gastroenterology 119:119–128

    PubMed  CAS  Google Scholar 

  • Schmieg J, Yang G, Franck RW, Van Rooijen N, Tsuji M (2005) Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion. Proc Natl Acad Sci U S A 102:1127–1132

    PubMed  CAS  Google Scholar 

  • Schofield L et al (1999) CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells. Science 283:225–229

    PubMed  CAS  Google Scholar 

  • Sieling PA et al (1999) CD1 expression by dendritic cells in human leprosy lesions: correlation with effective host immunity. J Immunol 162:1851–1858

    PubMed  CAS  Google Scholar 

  • Simmonds RE, Lane DA (1999) Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domains. Blood 94:632–641

    PubMed  CAS  Google Scholar 

  • Skold M, Xiong X, Illarionov PA, Besra GS, Behar SM (2005) Interplay of cytokines and microbial signals in regulation of CD1d expression and NKT cell activation. J Immunol 175:3584–3593

    PubMed  Google Scholar 

  • Small TN et al (1987) M241 (CD1) expression on B lymphocytes. J Immunol 138:2864–2868

    PubMed  CAS  Google Scholar 

  • Smith ME, Thomas JA, Bodmer WF (1988) CD1c antigens are present in normal and neoplastic B-cells. J Pathol 156:169–177

    PubMed  CAS  Google Scholar 

  • Somnay-Wadgaonkar K et al (1999) Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form. Int Immunol 11:383–392

    PubMed  CAS  Google Scholar 

  • Spada FM, Borriello F, Sugita M, Watts GF, Koezuka Y, Porcelli SA (2000) Low expression level but potent antigen presenting function of CD1d on monocyte lineage cells. Eur J Immunol 30:3468–3477

    PubMed  CAS  Google Scholar 

  • Sugita M et al (1996) Cytoplasmic tail-dependent localization of CD1b antigen-presenting molecules to MIICs. Science 273:349–352

    PubMed  CAS  Google Scholar 

  • Takahashi T, Haraguchi K, Chiba S, Yasukawa M, Shibata Y, Hirai H (2003) Valpha24+ natural killer T-cell responses against T-acute lymphoblastic leukaemia cells: implications for immunotherapy. Br J Haematol 122:231–239

    PubMed  Google Scholar 

  • Teitell M et al (1997) Nonclassical behavior of the mouse CD1 class I-like molecule. J Immunol 158:2143–2149

    PubMed  CAS  Google Scholar 

  • Trobonjaca Z, Leithauser F, Moller P, Bluethmann H et al (2001a) MHC-II-independent CD4+ T cells induce colitis in immunodeficient RAG-/- hosts. J Immunol 166:3804–3812

    PubMed  CAS  Google Scholar 

  • Trobonjaca Z, Leithauser F, Moller P, Schirmbeck R, Reimann J (2001b) Activating immunity in the liver. I. Liver dendritic cells (but not hepatocytes) are potent activators of IFN-gamma release by liver NKT cells. J Immunol 167:1413–1422

    PubMed  CAS  Google Scholar 

  • Tsuneyama K, Yasoshima M, Harada K, Hiramatsu K, Gershwin ME, Nakanuma Y (1998) Increased CD1d expression on small bile duct epithelium and epithelioid granuloma in livers in primary biliary cirrhosis. Hepatology 28:620–623

    PubMed  CAS  Google Scholar 

  • Ulanova M, Tarkowski A, Porcelli SA, Hanson LA (2000a) Antigen-specific regulation of CD1 expression in humans. J Clin Immunol 20:203–211

    PubMed  CAS  Google Scholar 

  • Ulanova M, Torebring M, Porcelli SA et al (2000b) Expression of CD1d in the duodenum of patients with cow’s milk hypersensitivity. Scand J Immunol 52:609–617

    PubMed  CAS  Google Scholar 

  • Van de Rijn M, Lerch PG, Knowles RW, Terhorst C (1983) The thymic differentiation markers T6 and M241 are two unusual MHC class I antigens. J Immunol 131:851–855

    PubMed  Google Scholar 

  • Van de Wal Y et al (2003) Delineation of a CD1d-restricted antigen presentation pathway associated with human and mouse intestinal epithelial cells. Gastroenterology 124:1420–1431

    PubMed  Google Scholar 

  • Van der Wel NN et al (2003) CD1 and major histocompatibility complex II molecules follow a different course during dendritic cell maturation. Mol Biol Cell 14:3378–3388

    PubMed  Google Scholar 

  • Wei B et al (2005) Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets. Proc Natl Acad Sci US A 102:2010–2015

    CAS  Google Scholar 

  • Woolfson A, Milstein C (1994) Alternative splicing generates secretory isoforms of human CD1. Proc Natl Acad Sci U S A 91:6683–6687

    PubMed  CAS  Google Scholar 

  • Wu DY, Segal NH, Sidobre S, Kronenberg M, Chapman PB (2003) Cross-presentation of disialoganglioside GD3 to natural killer T cells. J Exp Med 198:173–181

    PubMed  CAS  Google Scholar 

  • Xia CQ, Kao KJ (2002) Heparin induces differentiation of CD1a+ dendritic cells from monocytes: phenotypic and functional characterization. J Immunol 168:1131–1138

    PubMed  CAS  Google Scholar 

  • Yamazaki K, Ohsawa Y, Yoshie H (2001) Elevated proportion of natural killer T cells in periodontitis lesions: a common feature of chronic inflammatory diseases. Am J Pathol 158:1391–1398

    PubMed  CAS  Google Scholar 

  • Yang OO et al (2000) CD1d on myeloid dendritic cells stimulates cytokine secretion from and cytolytic activity of V alpha 24 J alpha QT cells: a feedback mechanism for immune regulation. J Immunol 165:3756–3762

    PubMed  CAS  Google Scholar 

  • Ylinen L et al (2000) The role of lipid antigen presentation, cytokine balance, and major histocompatibility complex in a novel murine model of adoptive transfer of insulitis. Pancreas 20:197–205

    PubMed  CAS  Google Scholar 

  • Yuan W, Dasgupta A, Cresswell P (2006) Herpes simplex virus evades natural killer T cell recognition by suppressing CD1d recycling. Nat Immunol 7:835–842

    PubMed  CAS  Google Scholar 

  • Yue SC, Shaulov A, Wang R, Balk SP, Exley MA (2005) CD1d ligation on human monocytes directly signals rapid NF-kappaB activation and production of bioactive IL-12. Proc Natl Acad Sci U S A 102:11811–11816

    PubMed  CAS  Google Scholar 

  • Zeng Z, Castano AR, Segelke BW, Stura EA, Peterson PA, Wilson IA (1997) Crystal structure of mouse CD1: an MHC-like fold with a large hydrophobic binding groove. Science 277:339–345

    PubMed  CAS  Google Scholar 

  • Zheng Z, Venkatapathy S, Rao G, Harrington CA (2002) Expression profiling of B cell chronic lymphocytic leukemia suggests deficient CD1-mediated immunity, polarized cytokine response, altered adhesion and increased intracellular protein transport and processing of leukemic cells. Leukemia 16:2429–2437

    PubMed  CAS  Google Scholar 

  • Zhou D, Cantu C 3rd, Sagiv Y, Schrantz N, Kulkarni AB, Qi X, Mahuran DJ, Morales CR, Grabowski GA, Benlagha K, Savage P, Bendelac A, Teyton L (2004) Editing of CD1d-bound-lipid antigens by endosomal lipid transfer proteins. Science 303:523–527

    PubMed  CAS  Google Scholar 

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Dougan, S.K., Kaser, A., Blumberg, R.S. (2007). CD1 Expression on Antigen-Presenting Cells. In: Moody, D.B. (eds) T Cell Activation by CD1 and Lipid Antigens. Current Topics in Microbiology and Immunology, vol 314. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69511-0_5

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