Conclusion
Comparing actual data to those of the previous surveys we again got very consistent findings indicating fairly good data quality. In addition our data are comparable to that of international large-scale prevalence studies and registry data. Despite mortality from HIV in patients with hemophilia is keeping on decreasing, HIV still remains an important factor as an HIV/HCV coinfection seems to increase risk of progression of liver disease to cirrhosis and hepatocellular carcinoma [5, 7]. In addition our findings stress the hypothesis that a relevant portion of patients reported dead of cancer might have died of primary hepatocellular carcinoma induced by chronic HCV. The fact that our data does not show an increasing number of patients with inhibitors over the last three decades does not support the thesis that recombinant factor VIII products induce a higher inhibitor risk.
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Krebs, H., Schramm, W. (2007). HIV Infection and Causes of Death in Patients with Hemophilia in Germany (Year 2004/2005 Survey). In: Scharrer, I., Schramm, W. (eds) 36th Hemophilia Symposium Hamburg 2005. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-36715-4_1
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