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Contributions of IL-22 to TH17 Responses: Repairing and Protecting Peripheral Tissues

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IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Despite its structural relationship with IL-10, IL-22 does not share any activity with this cytokine and appears, so far, completely devoid of activity on immune and hematopoietic cells. IL-22-responsive cells are mainly found in peripheral tissues and include keratinocytes, lung and intestinal epithelial cells, as well as hepatocytes. In vivo, IL-22 expression fits with the spectrum of inflammatory processes related to TH17 activation, including multiple sclerosis, inflammatory bowel disease, and psoriasis in human. However, its pathophysiological significance varies in each of these diseases. IL-22 does not seem to play any major role in multiple sclerosis, at least based on the classical mouse model for this disease. By contrast, this cytokine appears to play a protective role in mucosal inflammation and/or infections in both the lungs and colon. Finally, IL-22 turns out to be one of the main proinflammatory mediators responsible for inappropriate activation of keratinocytes in psoriasis lesions, raising some promising perspectives for future clinical applications.

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Authors and Affiliations

  1. Ludwig Institute for Cancer Research, UCL, 74.59 Avenue Hippocrate 74, Brussels, B-1200, Belgium

    Dr. Jean-Christophe Renauld

  2. Ludwig Institute for Cancer Research Ltd , and Experimental Medicine Unit, Universite catholique de Louvain, Avenue Hippocrate 74, Brussels, B-1200, Belgium

    Dr. Jean-Christophe Renauld & Laure Dumoutier

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  1. Dr. Jean-Christophe Renauld
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  2. Laure Dumoutier
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Correspondence to Jean-Christophe Renauld .

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Editors and Affiliations

  1. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orleans CX 2, 45071, France

    Valérie Quesniaux

  2. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orleans CX 2, 45071, France

    Bernhard Ryffel

  3. Novartis Institute for Biomedical, Research (NIBR), Novartis Pharma AG, Basel, 4002, Switzerland

    Franco Padova

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Renauld, JC., Dumoutier, L. (2013). Contributions of IL-22 to TH17 Responses: Repairing and Protecting Peripheral Tissues. In: Quesniaux, V., Ryffel, B., Padova, F. (eds) IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0522-3_4

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