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Th17 Cells in Transplantation: Actors or Innocent Bystanders?

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IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

The recent interest for Th17 cells immediately raised questions about their possible involvement in allogeneic processes. Indeed, IL-17-producing innate immune cells and Th17 cells have now been related to allograft rejection and ischemia-reperfusion injury in clinical settings and in experimental models. Some of them clearly established a link between the presence of these cells and the development of long-term graft dysfunction. A pivotal role of a Th17-mediated pathway in transplant damage has been demonstrated independently of MHC disparities with T cells recognizing either autoantigen or minor transplantation antigen. The ambiguous relationship between regulatory T cells (Treg) and Th17 cells also complicates Treg-based therapy. Herein, we briefly discuss recent studies reporting Th17 and IL-17 involvements in allograft rejection processes.

L-MC, BV, and PL are first coauthors.

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Acknowledgments

Ph. LM is supported by a grant from the Fonds National de la Recherche Scientifique (FNRS/FRSM) and B.V. by a grant from the Société Francophone de Transplantation (SFT). ALM is a researcher associate from the FNRS. A part of this work was supported by a ROTRF grant (Roche Organ Transplantation Research Foundation)

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Authors and Affiliations

  1. Institute for Medical Immunology, 8 rue Adrienne Bolland, Gosselies, 6041, Belgium

    Louis-Marie Charbonnier, Benoit Vokaer, Philippe Lemaître & Dr. Alain Le Moine

  2. Nephrology department, Erasme Hospital, Brussels, Belgium

    Dr. Alain Le Moine

Authors
  1. Louis-Marie Charbonnier
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  2. Benoit Vokaer
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  3. Philippe Lemaître
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  4. Dr. Alain Le Moine
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Corresponding author

Correspondence to Alain Le Moine .

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Editors and Affiliations

  1. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orleans CX 2, 45071, France

    Valérie Quesniaux

  2. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orleans CX 2, 45071, France

    Bernhard Ryffel

  3. Novartis Institute for Biomedical, Research (NIBR), Novartis Pharma AG, Basel, 4002, Switzerland

    Franco Padova

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Charbonnier, LM., Vokaer, B., Lemaître, P., Moine, A.L. (2013). Th17 Cells in Transplantation: Actors or Innocent Bystanders?. In: Quesniaux, V., Ryffel, B., Padova, F. (eds) IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0522-3_13

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  • DOI: https://doi.org/10.1007/978-3-0348-0522-3_13

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  • Publisher Name: Springer, Basel

  • Print ISBN: 978-3-0348-0521-6

  • Online ISBN: 978-3-0348-0522-3

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