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IL-17A Family, Receptors, Proinflammatory Effects, and Production

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IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

IL-17A is a proinflammatory cytokine with critical effects on many cell types. It is part of a larger family of cytokines with important roles in protection against pathogens. The IL-17A receptors are IL-17RA and IL-17RC. They are expressed on most cell types. IL-17A, in synergy with other cytokines such as TNF-α, induces the production of cytokines, chemokines, and mediators of tissue destruction in several cell types. The identification of IL-17A and, later on, of Th17 cells has modified the established Th1 and Th2 paradigm, led to the definition of a new CD3+ CD4+ effector T cell subset, and introduced a new paradigm to explain the origin of several autoimmune events. However, this paradigm shift tended also to identify the effects of IL-17A with those of Th17 cells and vice versa. This view might be insufficient to explain the role of IL-17A in infections and autoimmune models. IL-17A is in fact produced by several other cell types involved in host defense, autoimmunity, and inflammation, and they might also be involved in IL-17A induced pathology.

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Authors and Affiliations

  1. Novartis Institutes for Biomedical Research, WSJ 386-1048, Basel, CH-4002, Switzerland

    Franco Di Padova M.D.

  2. UMR7355 INEM, Experimental and Molecular Immunology and Neurogenetics, CNRS et Université d’Orleans, Orleans - Cedex 2, France

    Bernhard Ryffel M.D. & Valerie Quesniaux Ph.D.

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  1. Franco Di Padova M.D.
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  2. Bernhard Ryffel M.D.
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  3. Valerie Quesniaux Ph.D.
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Correspondence to Franco Di Padova M.D. .

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Editors and Affiliations

  1. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orleans CX 2, 45071, France

    Valérie Quesniaux

  2. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orleans CX 2, 45071, France

    Bernhard Ryffel

  3. Novartis Institute for Biomedical, Research (NIBR), Novartis Pharma AG, Basel, 4002, Switzerland

    Franco Padova

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Di Padova, F., Ryffel, B., Quesniaux, V. (2013). IL-17A Family, Receptors, Proinflammatory Effects, and Production. In: Quesniaux, V., Ryffel, B., Padova, F. (eds) IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0522-3_1

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  • DOI: https://doi.org/10.1007/978-3-0348-0522-3_1

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