Abstract
An overall assessment of the risks of adverse drug reactions and toxicity of OTC ibuprofen is considered and comparisons made with other OTC analgesics. Suggestions for reducing the occurrence of adverse reactions are proposed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Antman EM, Bennett JS, Daugherty A, Furberg C, Roberts H, Taubert KA (2007a) Use of nonsteroidal anti-inflammatory drugs. An update for clinicians. Circulation 115:1634–1642
Antman EM, Bennett JS, Daugherty A, Furberg C, Roberts H, Taubert KA, American Heart Association (2007b) Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association. Circulation 115:1634–1642
Ashraf E, Cooper S, Kellstein D, Jayawardena S (2001) Safety profile of non-prescription ibuprofen in the elderly osteoarthritic patient: a meta-analysis. Inflammopharmacology 9:35–41
Bjarnason I (2007) Ibuprofen and gastrointestinal safety: a dose-duration-dependent phenomenon. J R Soc Med 100:11–14
Brater DC (1998) Renal safety of ibuprofen: pharmacokinetic aspects. In: Rainsford KD, Powanda MC (eds) Safety and efficacy of non-prescription (OTC) analgesics and NSAIDs. Kluwer Academic, Dordrecht, pp 73–76
Doyle G, Furey S, Berlin R, Cooper S, Jayawardena S, Ashraf E, Baird L (1999) Gastrointestinal safety and tolerance of ibuprofen at maximum over-the-counter dose. Aliment Pharmacol Ther 13:897–906
Garcia-Rodriguez LA, Hernandez-Diaz S (2001) The risk of upper gastrointestinal complications associated with nonsteroidal anti-inflammatory drugs, glucocorticoids, acetaminophen, and combinations of these agents. Arthritis Res 3:98–101
Henry D, Lim LL-Y, Garcia Rodriguez LA, Perez Gutthann S, Carson JL, Griffin M, Savage R, Logan R, Moride Y, Hawkey C et al (1996) Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis. Br Med J 312:1563–1566
Henry DA, Drew A, Beuzeville S (1998) Adverse drug reactions in the gastrointestinal system attributed to ibuprofen. In: Rainsford KD, Powanda MC (eds) Safety and efficacy of non-prescription (OTC) analgesics and NSAIDs. Kluwer Academic, Dodrecht, pp 19–45
Le Parc JM, Van Ganse E, Moore N, Wall R, Schneid H, Verrière F (2002) Comparative tolerability of paracetamol, aspirin and ibuprofen for short-term analgesia in patients with musculoskeletal conditions: results in 4291 patients. Clin Rheumatol 21:28–31
Moore N, Van Ganse E, Le Parc J-M et al (1999) The PAIN study (Paracetamol, Aspirin and Ibuprofen New Tolerability study): a large-scale randomised clinical trial comparing the tolerability of aspirin, ibuprofen, and paracetamol for short-term analgesia. Clin Drug Invest 28:89–98
Moore N, Le Parc JM, van Ganse E, Wall R, Schneid H, Cairns R (2002) Tolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain. Int J Clin Pract 56:732–734
Moore N, Charlesworth A, Van Ganse E, LeParc JM, Jones JK, Wall R, Schneid H, Verrière F (2003) Risk factors for adverse events in analgesic drug users: results from the PAIN study. Pharmacoepidemiol Drug Saf 12:601–610
Rainsford KD (1999a) History and development of ibuprofen. In: Rainsford KD (ed) Ibuprofen: a critical bibliographic review. Taylor & Francis, London, pp 3–24
Rainsford KD (1999b) Pharmacology and toxicology of ibuprofen. In: Rainsford KD (ed) Ibuprofen: a critical bibliographic review. Taylor & Francis, London, pp 145–275
Rainsford KD (1999c) Safety and efficacy of non-prescription (OTC) ibuprofen. In: Rainsford KD (ed) Ibuprofen: a critical bibliographic review. Taylor & Francis, London, pp 357–405
Rainsford KD, Roberts SC, Brown S (1997) Ibuprofen and paracetamol: relative safety in non-prescription dosages. J Pharm Pharmacol 49:345–376
Strand V (2007) Are COX-2 inhibitors preferable to non-selective non-steroidal anti-inflammatory drugs in patients with risk of cardiovascular events taking low-dose aspirin? Lancet 370:2138–2151
Trelle S, Reichenbach S, Wandel S, Hildebrand P, Tschannen B, Villiger PM, Egger M, Jüni P (2011) Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. Br Med J 342:7086
Whitehouse MW, Rainsford KD (2006) Paracetamol (acetaminophen)-induced gastrotoxicity: revealed by induced hyperacidity in combination with acute or chronic inflammation. Inflammopharmacology 54:150–154
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer Basel
About this chapter
Cite this chapter
Rainsford, K.D. (2012). Overall Assessment. In: Ibuprofen: Pharmacology, Therapeutics and Side Effects. Springer, Basel. https://doi.org/10.1007/978-3-0348-0496-7_13
Download citation
DOI: https://doi.org/10.1007/978-3-0348-0496-7_13
Published:
Publisher Name: Springer, Basel
Print ISBN: 978-3-0348-0495-0
Online ISBN: 978-3-0348-0496-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)