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Acute Heart Failure pp 124–133Cite as

Mitochondrion: Key Factors in Acute Heart Failure

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Abstract

Mitochondria are largely abundant in the myocardium, not only because they provide the large part of energy in an organ that consumes a lot of adenosine triphosphate (ATP) for its mechanical activity and its cellular processes, but also because mitochondria play a potent role in cardiac homeostasis. Acute heart failure (AHF), defined as a reversible incapacity of the myocardium to provide a sufficient output for cellular metabolism of all the organs, is very common. Mechanisms leading to AHF have been largely investigated. Because the mitochondrial functional state is able to modulate force development and then pump function [1], impairment in cardiac contractile functions, as seen in AHF, may be the consequence of alterations in mitochondria function and metabolism. The role of mitochondria in AHF has been largely studied after ischemia-reperfusion injury and in septic shock. Besides these two situations, evidence of the role of mitochondria in AHF comes also from carbon monoxide (CO) poisoning where swollen mitochondria with rupture of mitochondrial cristae were described [2].

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Authors and Affiliations

  1. Department of Anaesthesiology and Critical Care Medicine, Lariboisière University Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Paris, France

    Christophe Rabuel MD

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  1. Christophe Rabuel MD
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Editors and Affiliations

  1. Department of Anesthesiology and Critical Care Medicine, Lariboisière University Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Paris, France

    Alexandre Mebazaa MD, PhD (Professor of Medicine) (Professor of Medicine)

  2. Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Mihai Gheorghiade MD, FACC (Professor of Medicine and Surgery, Associate Chief, Division of Cardiology and Chief, Cardiology Clinical Service) (Professor of Medicine and Surgery, Associate Chief, Division of Cardiology and Chief, Cardiology Clinical Service)

  3. Department of Cardiology Centre d’Investigation Clinique (CIC), INSERM U-684, Centre Hospitalier Universitaire, University Henri Poincaré, Nancy, France

    Faiez M. Zannad MD, PhD, FESC (Professor of Medicine) (Professor of Medicine)

  4. Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, NJ, USA

    Joseph E. Parrillo MD (Professor of Medicine, Chief, Department of Medicine Edward D. Viner MD Chair, Department of Medicine and Director) (Professor of Medicine, Chief, Department of Medicine Edward D. Viner MD Chair, Department of Medicine and Director)

  5. Cooper Heart Institute, Cooper University Hospital, Camden, NJ, USA

    Joseph E. Parrillo MD (Professor of Medicine, Chief, Department of Medicine Edward D. Viner MD Chair, Department of Medicine and Director) (Professor of Medicine, Chief, Department of Medicine Edward D. Viner MD Chair, Department of Medicine and Director)

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Rabuel, C. (2008). Mitochondrion: Key Factors in Acute Heart Failure. In: Mebazaa, A., Gheorghiade, M., Zannad, F.M., Parrillo, J.E. (eds) Acute Heart Failure. Springer, London. https://doi.org/10.1007/978-1-84628-782-4_13

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  • DOI: https://doi.org/10.1007/978-1-84628-782-4_13

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