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Gastroesophageal Reflux and IPF

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Idiopathic Pulmonary Fibrosis

Part of the book series: Respiratory Medicine ((RM,volume 9))

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Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing disease of the lung and the most common of the idiopathic interstitial pneumonias. The pathophysiology of IPF involves recurrent epithelial cell injury, abnormal wound repair responses, and aberrant fibroblast proliferation. Recent studies have shed light upon the potential role of gastroesophageal reflux (GER) and microaspiration as a possible etiology or trigger for the suspected recurrent epithelial injury and fibrosis that characterize IPF. Although acid aspiration has been linked to IPF, the mechanism and relationship of abnormal GER to the cause or progression of IPF have not been adequately addressed. This association is of great interest to the scientific and clinical communities, and active investigations are ongoing. Herein, we review what is currently understood about the relationship between GER and IPF and explore the evidence supporting this relationship.

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Authors and Affiliations

  1. Department of Medicine, Section of Pulmonary and Critical Care, University of Chicago Medical Center, 5841 S. Maryland Avenue, MC 6076, Chicago, IL, 60637, USA

    Stephenie M. Takahashi B.A., M.D., Karen C. Patterson M.D. & Imre Noth M.D.

  2. 1949 W. Argyle Street #2, Chicago, IL, 60640, USA

    Stephenie M. Takahashi B.A., M.D.

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  1. Stephenie M. Takahashi B.A., M.D.
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  2. Karen C. Patterson M.D.
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Correspondence to Stephenie M. Takahashi B.A., M.D. .

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  1. Dept. Internal Medicine, Sect. Allergy Pulmonary & Critical Care Med., University of Wisconsin School of Medicine & Public Health, Madison, Wisconsin, USA

    Keith C. Meyer

  2. Advanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, Virginia, USA

    Steven D. Nathan

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Takahashi, S.M., Patterson, K.C., Noth, I. (2014). Gastroesophageal Reflux and IPF. In: Meyer, K., Nathan, S. (eds) Idiopathic Pulmonary Fibrosis. Respiratory Medicine, vol 9. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-682-5_13

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  • DOI: https://doi.org/10.1007/978-1-62703-682-5_13

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