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Glycosylphosphatidylinositol Anchors As Natural Immunological Adjuvants Derived From Protozoan Parasites

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Vaccine Adjuvants

Part of the book series: Infectious Disease ((ID))

Abstract

Parasitism involves an intimate association between two different organisms. The host provides food and shelter for the parasite, and may or may not be injured by the parasite. As well elaborated in the book Living Together by William Trager (1), it is not in the best interest of the parasite to destroy the host. In the case of intracellular protozoan parasites that proliferate inside the vertebrate host cells, the immune system has a crucial role in controlling parasite replication and maintaining a balanced interaction between the parasite and the host, until the parasite encounters the transmitting vector or is shed to the environment to propagate its life cycle.

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Authors and Affiliations

  1. Department of Biochemistry and Immunology, Federal University of Minas Gerais, Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Belo Horizonte, Brazil

    Ricardo T. Gazzinelli DVM, PhD & Marco A. Campos PhD

  2. Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Belo Horizonte, Brazil

    Catherine Ropert PhD

  3. Department of Parasitology, University of São Paulo, São Paulo, Brazil

    Igor C. Almeida PhD

  4. Department of Biochemistry and Immunology, University of São Paulo, São Paulo, Brazil

    João S. Silva PhD

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  1. Ricardo T. Gazzinelli DVM, PhD
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  2. Catherine Ropert PhD
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  3. Igor C. Almeida PhD
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  4. João S. Silva PhD
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  5. Marco A. Campos PhD
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Editors and Affiliations

  1. Division of Allergy, Immunology, and Transplantation National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD

    Charles J. Hackett PhD

  2. Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA

    Donald A. Harn Jr. MD

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Gazzinelli, R.T., Ropert, C., Almeida, I.C., Silva, J.S., Campos, M.A. (2006). Glycosylphosphatidylinositol Anchors As Natural Immunological Adjuvants Derived From Protozoan Parasites. In: Hackett, C.J., Harn, D.A. (eds) Vaccine Adjuvants. Infectious Disease. Humana Press. https://doi.org/10.1007/978-1-59259-970-7_8

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