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Dendritic Cells

Targets for Immune Modulation by Microbes and Immunologists

  • Chapter
Vaccine Adjuvants

Part of the book series: Infectious Disease ((ID))

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Abstract

Since the original description of Th1 and Th2 T cells by Mosman and Coffman some 15 years ago (1), there has been a profusion of knowledge about the cytokines that influence the type of Th response. Thus, interleukin 4 (IL)-4 is known to induce IL-4 production in T cells; conversely IL-12 and interferon (IFN)γ are known to induce IFNγ production by T cells. However, the original sources of these cytokines in vivo, and the mechanisms that initiate one or another response, are less clear. Recent developments from several labs point to a potential role for dendritic cells (DCs) in orchestrating this decision. Here, we present our current view of DC development in vivo and then review the literature that suggest that distinct DC subsets may direct Th responses differently. These ideas are discussed in the context that the Th polarizing potentials of DC subsets are not fixed, but are rather plastic. Given their pivotal roles in immunity, DCs represent prime targets for immune modulation by both microbes, and immunologists. Some examples of immune modulation by microbes, and prospects for clinical utility are briefly considered.

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Authors and Affiliations

  1. Department of Pathology, Emory Vaccine Center, Emory University, Atlanta, GA

    Bali Pulendran PhD, Anshu Agrawal PhD, Stephanie Dillon PhD & Sudhanshu Agrawal

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  1. Bali Pulendran PhD
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  2. Anshu Agrawal PhD
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  3. Stephanie Dillon PhD
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Editors and Affiliations

  1. Division of Allergy, Immunology, and Transplantation National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD

    Charles J. Hackett PhD

  2. Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA

    Donald A. Harn Jr. MD

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Pulendran, B., Agrawal, A., Dillon, S., Agrawal, S. (2006). Dendritic Cells. In: Hackett, C.J., Harn, D.A. (eds) Vaccine Adjuvants. Infectious Disease. Humana Press. https://doi.org/10.1007/978-1-59259-970-7_2

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