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Short Chain Fatty Acids, Intestinal Adaptation, and Nutrient Utilization

  • Chapter
Dietary Fiber in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 427))

Abstract

The gut, composed of epithelial cells, gut associated immune cells, and smooth muscle cells, is a highly dynamic organ recognized for its role in nutrient absorption and the exclusion of foreign substances, ie gut barrier function. Less well understood is its influence on the utilization of nutrients even though > 50% of the post-prandial insulin response is mediated by gut-secreted peptides (the “incretin” effect)1,2. Thus, a consideration of the effect of dietary fiber on nutrient utilization must consider two domains: 1) the requirement of the gut for nutrients per se and 2) the secretion of peptides from the gut to potentially influence nutrient utilization in other tissues.

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Authors and Affiliations

  1. Nutrition & Metabolism Research Group Departments of Agriculture, Food and Nutritional Science, and Medicine, University of Alberta, Edmonton, AB, T6G 2P5, Canada

    M. I. McBurney, R. A. Reimer & K. A. Tappenden

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  1. M. I. McBurney
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  2. R. A. Reimer
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  3. K. A. Tappenden
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  1. The Wistar Institute, Philadelphia, Pennsylvania, USA

    David Kritchevsky

  2. Clinical Review Associates, McLean, Virginia, USA

    Charles Bonfield

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McBurney, M.I., Reimer, R.A., Tappenden, K.A. (1997). Short Chain Fatty Acids, Intestinal Adaptation, and Nutrient Utilization. In: Kritchevsky, D., Bonfield, C. (eds) Dietary Fiber in Health and Disease. Advances in Experimental Medicine and Biology, vol 427. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5967-2_15

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