Abstract
Traditionally, the etiology of PTSD has been construed in psychological terms, such as learned conditioning (Keane et al., 1985), shattered cognitive assumptions (Janoff Bullman, 1985), or impacted grief (Horowitz, 1974). Such understanding reflected an early belief about PTSD, according to which the disorder was an extension of a normal response to extreme events, and its persistence over time was mediated by “unresolved” psychological processes. The current trend of imputing all mental disorders to underlying brain pathology has not spared PTSD. Current biological formulations of PTSD emphasize the pathogenic effects of environmental “stressors” on (predisposed?) brain structures, and PTSD is the expression of the resulting neuropathology. Biological therapies attempt to redress, reduce, or balance such hypothetical dysfunction of the brain.
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Shalev, A.Y., Bonne, O. (2000). Pharmacological Treatment of Trauma-Related Disorders. In: Shalev, A.Y., Yehuda, R., McFarlane, A.C. (eds) International Handbook of Human Response to Trauma. Springer Series on Stress and Coping. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4177-6_26
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